Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2021; 9(31): 9670-9679
Published online Nov 6, 2021. doi: 10.12998/wjcc.v9.i31.9670
Brunner’s gland hyperplasia associated with lipomatous pseudohypertrophy of the pancreas presenting with gastrointestinal bleeding: A case report
Long Cong Nguyen, Khanh Truong Vu, Trang Thi Thuy Vo, Chau Ha Trinh, Tan Dang Do, Ngoc Thi Van Pham, Tuyen Van Pham, Thanh Tuan Nguyen, Hiep Canh Nguyen, Jeong-Sik Byeon
Long Cong Nguyen, Khanh Truong Vu, Trang Thi Thuy Vo, Ngoc Thi Van Pham, Gastroenterology and Hepatology Center, Bach Mai Hospital, Hanoi 10000, Viet Nam
Long Cong Nguyen, Khanh Truong Vu, Department of Gastroenterology, School of Medicine and Pharmacy, Vietnam National University Hanoi, Hanoi 10000, Viet Nam
Chau Ha Trinh, Tan Dang Do, Radiology Center, Bach Mai Hospital, Hanoi 10000, Viet Nam
Tuyen Van Pham, Thanh Tuan Nguyen, Hiep Canh Nguyen, Pathology Center, Bach Mai Hospital, Hanoi 10000, Viet Nam
Hiep Canh Nguyen, Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920-8640, Japan
Jeong-Sik Byeon, Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea
Author contributions: Nguyen LC conceived and wrote the manuscript; Byeon JS performed the operation and edited the manuscript; Vo TTT and Pham NTV analyzed the data; Pham TV, Nguyen TT and Nguyen HC performed the operation; Vu KT performed the Esophagogastroduodenoscopy examination; Nguyen HC, Trinh CH and the other authors discussed the results together and contributed to the final manuscript; all authors read and approved the final manuscript.
Supported by School of Medicine and Pharmacy, Vietnam National University Hanoi, Hanoi, Viet Nam, No. QGSP.2021.06.
Informed consent statement: Informed written consent was obtained from the patients for the publication of these reports and any accompanying images.
Conflict-of-interest statement: There is no conflict of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Long Cong Nguyen, MD, Deputy Director, Gastroenterology and Hepatology Center, Bach Mai Hospital, 78, Giai Phong Street, Hanoi 10000, Viet Nam. nguyenconglongbvbm@gmail.com
Received: June 6, 2021
Peer-review started: June 6, 2021
First decision: June 25, 2021
Revised: August 26, 2021
Accepted: September 19, 2021
Article in press: September 19, 2021
Published online: November 6, 2021
Processing time: 145 Days and 8.7 Hours
Core Tip

Core Tip: Brunner’s gland hyperplasia (BGH) and lipomatous pseudohypertrophy (LiPH) of the pancreas are rare diseases. We present a case with coexisting LiPH of the pancreas and a huge pedunculated BGH of the duodenum that presented with upper gastrointestinal bleeding. Esophagogastroduodenoscopy revealed a large submucosal mass along the duodenum with central ulceration, and radiological examination showed marked thickening of the duodenal walls and fatty replacement over the entire pancreatic parenchyma. Diagnoses of BGH and LiPH were confirmed by histological evaluations. Although rare, BGH can cause gastrointestinal bleeding. Furthermore, this case highlights the usefulness of combined esophagogastroduodenoscopy and radiological examinations in patients with melena.