Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2021; 9(31): 9557-9563
Published online Nov 6, 2021. doi: 10.12998/wjcc.v9.i31.9557
Validation of diagnostic strategies of autoimmune atrophic gastritis: A case report
Wen-Jing Sun, Qiang Ma, Ren-Zheng Liang, Ya-Mei Ran, Li Zhang, Juan Xiao, Yong-Mei Peng, Bin Zhan
Wen-Jing Sun, Ren-Zheng Liang, Ya-Mei Ran, Li Zhang, Juan Xiao, Yong-Mei Peng, Bin Zhan, Department of Gastroenterology, Hepatology and Endocrinology, Thirteenth Peoples’ Hospital of Chongqing, Chongqing 400053, China
Qiang Ma, Department of Pathology, Daping Hospital, Army Medical University, Chongqing 400042, China
Author contributions: Sun WJ contributed to diagnosis, drafting the manuscript and reviewing the literature; Ma Q performed the pathological diagnosis; Liang RZ performed the endoscopy and management of the patient; Zhang L, Xiao J and Peng YM reviewed the literature; Zhan B manage the patient as the cooperation teacher and contributed to the revising the manuscript, reference list and original figure documents.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bin Zhan, MD, Chief Physician, Department of Gastroenterology, Hepatology and Endocrinology, Thirteenth Peoples’ Hospital of Chongqing, No. 16 Tieluxincun, Jiulongpo District, Chongqing 400053, China. 406302524@qq.com
Received: June 6, 2021
Peer-review started: June 6, 2021
First decision: July 5, 2021
Revised: July 13, 2021
Accepted: September 6, 2021
Article in press: September 6, 2021
Published online: November 6, 2021
Core Tip

Core Tip: The mechanism of autoimmune atrophic gastritis (AAG) involves H+-K+ ATPase. It is mostly identified during the late stage due to pernicious anemia. We present a case of AAG with anemia, typical endoscopic findings and immunohistochemical staining for H+-K+ ATPase and chromogranin A (CgA) antibodies. This case report demonstrates a successful diagnostic strategy for AAG that includes serological test (anti-parietal cell and anti-intrinsic factor antibodies), endoscopic characteristics and immunohistochemical results for H+-K+ ATPase and CgA antibodies.