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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2021; 9(31): 9481-9490
Published online Nov 6, 2021. doi: 10.12998/wjcc.v9.i31.9481
Published online Nov 6, 2021. doi: 10.12998/wjcc.v9.i31.9481
Retrospective analysis of influencing factors on the efficacy of mechanical ventilation in severe and critical COVID-19 patients
Jia Zeng, Department of Aviation Disease, Naval Medical Center of PLA, Shanghai 200052, China
Jia Zeng, No. 1 Department of Infection, Optical Valley Campus of Hubei Maternal and Child Health Care Hospital, Wuhan 430073, Hubei Province, China
Xiao-Xia Qi, Department of Traditional Chinese Medicine, Naval Medical Center of PLA, Shanghai 200052, China
Wan-Wan Cai, Department of Naval Diving Medicine, Naval Medical Center of PLA, Shanghai 200052, China
Ya-Ping Pan, Traditional Chinese Medicine, Naval Medical Center of PLA, Shanghai 200052, China
Yi Xie, Department of Hepatobiliary Surgery, Naval Medical Center of PLA, Shanghai 200052, China
Author contributions: Zeng J and Qi XX contributed equally to this work; Zeng J and Qi XX designed the research; Zeng J, Jiang WW, and Pan YP collected and analyzed the clinical data; Zeng J, Qi XX, and Xie Y wrote the manuscript; Xie Y revised the manuscript.
Institutional review board statement: This study was reviewed and approved by the Optical Valley Campus of the Hubei Maternal and Child Health Care Hospital Institutional Review Board (Approval No. FYGG(L)-2020-020) and Naval Medical University Institutional Review Board (Approval No. LW20160040).
Informed consent statement: Patients were not required to give informed consent to this study because the analysis used anonymous clinical data that was obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: No additional data is available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jia Zeng, MBBS, Associate Chief Physician, Department of Aviation Disease, Naval Medical Center of PLA, No. 338 Huaihai West Road, Changning District, Shanghai 200052, China. yijiacheng455@163.com
Received: June 22, 2021
Peer-review started: June 22, 2021
First decision: July 5, 2021
Revised: July 28, 2021
Accepted: August 25, 2021
Article in press: August 25, 2021
Published online: November 6, 2021
Peer-review started: June 22, 2021
First decision: July 5, 2021
Revised: July 28, 2021
Accepted: August 25, 2021
Article in press: August 25, 2021
Published online: November 6, 2021
Core Tip
Core Tip: A total of 27 severe and critical coronavirus disease 2019 (COVID-19) patients were treated with mechanical ventilation and divided into the “effective group” and “death group” according to the final outcomes of the treatment. There were significant differences in the degree of infection, cardiac and renal function, and blood glucose between the death group and effective group. We found that age, blood glucose, cardiac and renal function, and inflammatory reaction are important indicators of poor prognosis for mechanical ventilation in severe and critical COVID-19 patients.