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World J Clin Cases. Nov 6, 2021; 9(31): 9368-9375
Published online Nov 6, 2021. doi: 10.12998/wjcc.v9.i31.9368
Gene × environment interaction in major depressive disorder
Ming-Zhe Zhao, Xu-Sheng Song, Jing-Song Ma
Ming-Zhe Zhao, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China
Xu-Sheng Song, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China
Jing-Song Ma, Institute of Advanced Technology, Westlake Institute for Advanced Study, Hangzhou 310024, Zhejiang Province, China
Jing-Song Ma, School of Engineering, Westlake University, Hangzhou 310024, Zhejiang Province, China
Author contributions: Zhao MZ and Ma JS designed this study; Zhao MZ and Song XS wrote and revised the paper; All authors were involved in editing the manuscript.
Conflict-of-interest statement: There is no conflict of interest associated with the contributions of the senior author or coauthors of this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing-Song Ma, MD, Postdoc, Institute of Advanced Technology, Westlake Institute for Advanced Study, No. 18 Shilongshan Road, Hangzhou 310024, Zhejiang Province, China. majingsong@westlake.edu.cn
Received: February 20, 2021
Peer-review started: February 20, 2021
First decision: May 13, 2021
Revised: May 27, 2021
Accepted: August 17, 2021
Article in press: August 17, 2021
Published online: November 6, 2021
Processing time: 251 Days and 0.6 Hours
Core Tip

Core Tip: The effects of environmental factors on the risk of developing major depressive disorder are likely to be moderated by genetic variants which confer a sensitivity to both positive and negative environmental factors.