Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2021; 9(28): 8563-8570
Published online Oct 6, 2021. doi: 10.12998/wjcc.v9.i28.8563
Genetic characteristics of a patient with multiple primary cancers: A case report
Wei-Wei Ouyang, Qing-Yun Li, Wen-Gang Yang, Sheng-Fa Su, Li-Jia Wu, Ying Yang, Bing Lu
Wei-Wei Ouyang, Wen-Gang Yang, Sheng-Fa Su, Bing Lu, Department of Thoracic Oncology, The Affiliated Hospital of Guizhou Medical University and Cancer Hospital of Guizhou Medical University, Guiyang 550000, Guizhou Province, China
Qing-Yun Li, Li-Jia Wu, Ying Yang, Genecast Biotechnology Co., Ltd, Wuxi 214104, Jiangsu Province, China
Author contributions: Lu B designed the research project; Li QY drafted the manuscript; Ouyang WW and Yang WG were responsible for the treatment of the patient; Ouyang WW collected the patient’ clinical data; Wu LJ and Yang Y performed the data analyses; Su SF assisted in the writing of the manuscript; all authors have read and approved the manuscript.
Informed consent statement: Informed consent was obtained from the patient prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no competing interests to report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bing Lu, MD, Doctor, Department of Thoracic Oncology, The Affiliated Hospital of Guizhou Medical University and Cancer Hospital of Guizhou Medical University, No. 1 West Beijing Road, Yunyan District, Guiyang 550000, Guizhou Province, China. lbgymaaaa@163.com
Received: May 27, 2021
Peer-review started: May 27, 2021
First decision: June 15, 2021
Revised: June 28, 2021
Accepted: August 2, 2021
Article in press: August 2, 2021
Published online: October 6, 2021
Processing time: 124 Days and 0.9 Hours
Core Tip

Core Tip: We report a case of multiple primary malignant neoplasms. In this case, next-generation whole exome sequencing confirmed that esophageal squamous-cell carcinoma and gastrointestinal stromal tumour were not genetically evolved from rectal adenocarcinoma that was removed 3 years ago but occurred independently. The results of next-generation whole exome sequencing of the tumour tissues confirmed the specimens’ evolution relationship.