Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2021; 9(28): 8552-8556
Published online Oct 6, 2021. doi: 10.12998/wjcc.v9.i28.8552
Spinocerebellar ataxia type 3 with dopamine-responsive dystonia: A case report
Xiao-Le Zhang, Xiao-Bo Li, Fa-Feng Cheng, Shu-Ling Liu, Wen-Chao Ni, Fei-Fei Tang, Qing-Guo Wang, Xue-Qian Wang
Xiao-Le Zhang, Fa-Feng Cheng, Shu-Ling Liu, Wen-Chao Ni, Fei-Fei Tang, Qing-Guo Wang, Xue-Qian Wang, School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China
Xiao-Bo Li, Internal Medicine-Neurology, Xi'an Third Hospital, Xi'an 710000, Shaanxi Province, China
Author contributions: Zhang XL and Li XB contributed equally to this work, and were responsible for research conception and design, data collation and interpretation, and manuscript drafting; Cheng FF, Liu SL, Ni WC, Tang FF, Wang QG and Wang XQ revised the manuscript for important intellectual content and gave English writing guidance; all authors reviewed and approved the final version to be published.
Supported by the National Natural Science Foundation of China, No. 81874448 and No. 81973789.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article are reported.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CAREChecklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Qian Wang, MD, Chief Doctor, Professor, School of Basic Medical Sciences, Beijing University of Chinese Medicine, No. 11 Beisanhuandong Road, Beijing 100029, China. wxqbucm@126.com
Received: May 27, 2021
Peer-review started: May 27, 2021
First decision: June 24, 2021
Revised: June 28, 2021
Accepted: August 18, 2021
Article in press: August 18, 2021
Published online: October 6, 2021
Core Tip

Core Tip: We report a female patient initially diagnosed with dopamine-responsive dystonia. After treatment with low-dose levodopa, the patient’s symptoms were significantly improved, but she was ultimately diagnosed with spinocerebellar ataxia type 3 (SCA3) by genetic testing. Sensitivity to levodopa may be a clinical feature of SCA3, and this report could add to the evidence of the SCA3 clinical phenotypes, which need to be differentiated from Parkinson's syndrome and dopamine-responsive dystonia.