Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2021; 9(28): 8492-8497
Published online Oct 6, 2021. doi: 10.12998/wjcc.v9.i28.8492
Extremely high titer of hepatitis B surface antigen antibodies in a primary hepatocellular carcinoma patient: A case report
Jing-Jing Han, Yu Chen, Yu-Chen Nan, Yong-Lin Yang
Jing-Jing Han, Yu Chen, Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Yu-Chen Nan, Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling 712100, Shaanxi Province, China
Yong-Lin Yang, Department of Infectious Disease, Taizhou Clinical Medical School of Nanjing Medical University (Taizhou People's Hospital), Taizhou 225300, Jiangsu Province, China
Yong-Lin Yang, Department of General Practice, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, Jiangsu Province, China
Author contributions: Yang YL was the patient’s attending, and responsible for making critical revisions related to important intellectual content of the manuscript; Han JJ reviewed the literature and contributed to manuscript drafting; Nan YC and Chen Y were responsible for revision of the manuscript for important intellectual content; All authors issued final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Yong-Lin Yang, MD, Chief Doctor, Department of Infectious Disease, Taizhou Clinical Medical School of Nanjing Medical University (Taizhou People's Hospital), No. 210 Yingchun Road, Hailing District, Taizhou 225300, Jiangsu Province, China.
Received: April 1, 2021
Peer-review started: April 1, 2021
First decision: May 27, 2021
Revised: May 28, 2021
Accepted: August 11, 2021
Article in press: August 11, 2021
Published online: October 6, 2021
Core Tip

Core Tip: Generally, hepatitis B surface antigen turning negative and the occurrence of hepatitis B surface antibody have been regarded as indicators of virus clearance and clinical recovery in hepatitis B patients. Here, we present a case of hepatis B virus (HBV) infection-associated hepatocellular carcinoma with extreme high titer of hepatitis B surface antibodies, up to 30396 mIU/mL, and failure to eliminate HBV. This case provides details of a diagnostic process for HBV infection-associated hepatocellular carcinoma that should be considered in patients with highly elevated titer of anti-HBs.