Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 6, 2021; 9(25): 7484-7489
Published online Sep 6, 2021. doi: 10.12998/wjcc.v9.i25.7484
Octreotide-induced acute life-threatening gallstones after vicarious contrast medium excretion: A case report
Zong-Hong Han, Zhong-Ming He, Wen-Hua Chen, Cao-Ye Wang, Qi Wang
Zong-Hong Han, Zhong-Ming He, Wen-Hua Chen, Cao-Ye Wang, Qi Wang, Department of Interventional Radiology, The First People’s Hospital of Changzhou, Changzhou 213003, Jiangsu Province, China
Author contributions: Han ZH and Wang CY conceived and designed the research; He ZM and Chen WH acquired data; Han ZH and Wang Q prepared and revised the manuscript; Chen WH provided helpful suggestions about the study; All authors issued final approval of the version for submission.
Supported by the Changzhou Commission of Health, No. WZ201904.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi Wang, MD, Chief Doctor, Department of Interventional Radiology, The First People’s Hospital of Changzhou, No. 185 Juqian Street, Changzhou 213003, Jiangsu Province, China. czwangqi666@sina.com
Received: January 16, 2021
Peer-review started: January 16, 2021
First decision: April 29, 2021
Revised: May 12, 2021
Accepted: July 16, 2021
Article in press: July 16, 2021
Published online: September 6, 2021
Processing time: 226 Days and 23.4 Hours
Core Tip

Core Tip: Vicarious contrast medium (CM) excretion (VCME) through the hepatobiliary system is well known. Long-term octreotide treatment can increase the incidence of gallstones. In this case, acute gallstones may have been induced by octreotide after VCME through the hepatobiliary system. When the CM was excreted into the hepatobiliary system, which was retained for a long time and concentrated by octreotide, it might change the physicochemical properties of bile and decreased nucleation time, finally resulting in the formation of acute gallstones.