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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 6, 2021; 9(25): 7468-7471
Published online Sep 6, 2021. doi: 10.12998/wjcc.v9.i25.7468
Published online Sep 6, 2021. doi: 10.12998/wjcc.v9.i25.7468
Agranulocytosis following injection of inactivated Japanese encephalitis vaccine (Vero cell): A case report
Li Wang, Yan-Tao Liu, Department of Pharmacy, West China Second University Hospital, Sichuan University/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu 610041, Sichuan Province, China
Xu Zhang, Department of Pharmacy, West China Second University Hospital, Sichuan University/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu 610041, Sichuan Province, China/Department of Pharmacy, Dechang People's Hospital, Liangshan 615500, Sichuan Province, China
Author contributions: Wang L reviewed the literature and drafted the manuscript; Zhang X was responsible for the revision of the manuscript for important intellectual content; Liu YT reviewed the literature and contributed to manuscript drafting; all authors issued final approval for the version to be submitted.
Informed consent statement: Written informed consent was obtained from the patient’s parents for publication of this case and accompanying images.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Tao Liu, MSc, Associate Professor, Department of Pharmacy, West China Second University Hospital, Sichuan University/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, No. 20, Section 3, South Renmin Road, Chengdu 610041, Sichuan Province, China.
Received: December 25, 2020
Peer-review started: December 25, 2020
First decision: May 11, 2021
Revised: May 25, 2021
Accepted: July 16, 2021
Article in press: July 16, 2021
Published online: September 6, 2021
Processing time: 248 Days and 17.6 Hours
Peer-review started: December 25, 2020
First decision: May 11, 2021
Revised: May 25, 2021
Accepted: July 16, 2021
Article in press: July 16, 2021
Published online: September 6, 2021
Processing time: 248 Days and 17.6 Hours
Core Tip
Core Tip: So far, there has been no report of vaccine-induced neutropenia that persisted for 2 years until recovery. Japanese Encephalitis virus, a mosquito borne flavivirus, is the leading cause of viral encephalitis in Asia, in terms of frequency and severity. This report attempts to bring to clinical attention that Inactivated Japanese Encephalitis Vaccine (Vero cell) might cause prolonged neutropenia or even agranulocytosis.