Systematic Reviews
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 6, 2021; 9(25): 7433-7444
Published online Sep 6, 2021. doi: 10.12998/wjcc.v9.i25.7433
Association between COVID-19 and anxiety during social isolation: A systematic review
Erlene Roberta Ribeiro dos Santos, Jose Lucas Silva de Paula, Felipe Maia Tardieux, Vânia Nazaré Costa-e-Silva, Amos Lal, Antonio Flaudiano Bem Leite
Erlene Roberta Ribeiro dos Santos, Department of Neuropsychiatry and Behavioral Science-Neurosciences, Research Circle on Technologies, Strategies and Instruments Applied to Collective Health, Vitória de Santo Antão 55608680, Brazil
Jose Lucas Silva de Paula, Felipe Maia Tardieux, Department of Collective Health, Research Circle on Technologies, Strategies and Instruments Applied to Collective Health, Vitória de Santo Antão 55608680, Brazil
Vânia Nazaré Costa-e-Silva, State Audit Component of the Unified Health System, State Health Secretariat, Recife 50751530, Brazil
Amos Lal, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN 55905, United States
Antonio Flaudiano Bem Leite, Department of Epidemiological Surveillance, Henrique de Holanda, Municipal Health Secretariat, Vitória de Santo Antão 55608680, Brazil
Author contributions: Santos ERRD and Costa-e-Silva VN designed the research; Santos ERRD, Tardieux FM and Silva de Paula JL performed the research; Santos ERRD, Tardieux FM and Silva de Paula JL analyzed the data; Santos ERRD, Costa-e-Silva VN, Silva de Paula JL and Leite AFB wrote the paper; Santos ERRD, Silva de Paula JL, Tardieux FM, Costa-e-Silva VN, Lal A and Leite AFB supervised the paper; all authors read and approved the final manuscript.
Conflict-of-interest statement: No conflict of interests.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Amos Lal, FACP, MBBS, Assistant Professor, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 1st Street, Rochester, MN 55905, United States. manavamos@gmail.com
Received: February 5, 2021
Peer-review started: February 5, 2021
First decision: March 7, 2021
Revised: March 17, 2021
Accepted: August 13, 2021
Article in press: August 13, 2021
Published online: September 6, 2021
Core Tip

Core Tip: There is a potential relationship between social isolation during the coronavirus disease 2019 pandemic and symptoms of anxiety. The population between the age of 21 to 40 years is notably most affected. The risk of severe depression is noted to be twice as high at the epicenter of the pandemic. Sleep quality was significantly impaired. It is important to note that the direct and indirect costs of not identifying the detrimental effects of this phenomenon and neglecting strategies for intervention could lead to a significant psychological burden on society in several aspects after social isolation.