Retrospective Cohort Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2021; 9(24): 6999-7008
Published online Aug 26, 2021. doi: 10.12998/wjcc.v9.i24.6999
Cost-effective screening using a two-antibody panel for detecting mismatch repair deficiency in sporadic colorectal cancer
Jong Beom Kim, Young Il Kim, Yong Sik Yoon, Jihun Kim, Seo Young Park, Jong Lyul Lee, Chan Wook Kim, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim
Jong Beom Kim, Young Il Kim, Yong Sik Yoon, Jong Lyul Lee, Chan Wook Kim, In Ja Park, Seok-Byung Lim, Chang Sik Yu, Jin Cheon Kim, Division of Colon and Rectal Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, South Korea
Jihun Kim, Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, South Korea
Seo Young Park, Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, South Korea
Author contributions: Kim JB and Kim YI contributed equally to this article. Kim JB contributed to data acquisition, analysis, interpretation, and wrote the paper; Yoon YS contributed to research design, and supervised the report; Kim J contributed to research design, and contributed to the analysis; Kim YI revised the manuscript; Yoon YS, Kim J should be considered as joint corresponding authors; Park SY proposed an appropriate statistical analysis method; Kim YI, Lee JL, Kim CW, Park IJ, Lim SB, Yu CS, Kim JC provided clinical advice; all authors read and approved the manuscript.
Supported by the Asan Institute for Life Sciences, Asan Medical Center, Seoul, South Korea, No. 2020IP0039.
Institutional review board statement: The study’s protocol was reviewed and approved by the institutional review board of our institution (IRB No. 2019-7777).
Informed consent statement: Data was anonymous and informed consent was waived by the IRB.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement, and the manuscript was prepared and revised according to the STROBE Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong Sik Yoon, MD, PhD, Professor, Division of Colon and Rectal Surgery, University of Ulsan College of Medicine, Asan Medical Center, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea. yoonys@amc.seoul.kr
Received: December 29, 2020
Peer-review started: December 29, 2020
First decision: May 2, 2021
Revised: May 24, 2021
Accepted: July 23, 2021
Article in press: July 23, 2021
Published online: August 26, 2021
Processing time: 237 Days and 17.7 Hours
Core Tip

Core Tip: Screening for mismatch repair deficiency in sporadic colorectal cancer has not been established. This study compared microsatellite instability test to four- and two types of two-antibody panels of immunohistochemistry. A two-antibody panel of PMS2/MSH6 may be the best choice in terms of balancing cost-effectiveness and accuracy for screening.