Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2021; 9(17): 4365-4372
Published online Jun 16, 2021. doi: 10.12998/wjcc.v9.i17.4365
Kidney re-transplantation after living donor graft nephrectomy due to de novo chromophobe renal cell carcinoma: A case report
Hui Wang, Wen-Li Song, Wen-Juan Cai, Gang Feng, Ying-Xin Fu
Hui Wang, Wen-Li Song, Gang Feng, Ying-Xin Fu, Department of Kidney and Pancreas Transplant, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China
Wen-Juan Cai, Department of Pathology, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin 300192, China
Author contributions: Wang H summarized the clinical data and drafted the manuscript; Feng G contributed to the conception of the study and final approval of the version of the article to be published; Song WL, Feng G, and Wang H performed transplant surgery; Cai WJ contributed to acquisition and interpretation of pathological images; Fu YX contributed to the conception of the study.
Supported by National Natural Science Foundation of , No. 81970654.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gang Feng, MD, PhD, Chief Doctor, Surgeon, Department of Kidney and Pancreas Transplant, Tianjin First Central Hospital, School of Medicine, Nankai University, No. 24 Fukang Road, Nankai District, Tianjin 300192, China. fengganghtc@163.com
Received: January 23, 2021
Peer-review started: January 23, 2021
First decision: February 11, 2021
Revised: February 15, 2021
Accepted: March 29, 2021
Article in press: March 29, 2021
Published online: June 16, 2021
Core Tip

Core Tip: Chromophobe renal cell carcinoma (ChRCC) is a rare malignancy of kidney allografts. This paper presents a case of de novo ChRCC arising primarily in an allograft kidney many years post-transplantation. It was successfully managed by allograft nephrectomy, and 2 years later, the patient underwent successful re-transplantation. Graft function was stable with no ChRCC recurrence beyond 2 years after re-transplantation. There are no guidelines for kidney re-transplantation after graft nephrectomy due to graft cancer. It remains a challenge to balance prevention of allosensitization and recurrence of cancer.