Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 26, 2021; 9(15): 3741-3751
Published online May 26, 2021. doi: 10.12998/wjcc.v9.i15.3741
Alopecia treatment using minimally manipulated human umbilical cord-derived mesenchymal stem cells: Three case reports and review of literature
Hyunjun Ahn, Sang Yeon Lee, Won Ju Jung, Kye-Ho Lee
Hyunjun Ahn, Sang Yeon Lee, Kye-Ho Lee, bio Beauty&Health Company (bBHC) - Stem Cell Treatment & Research Institute (STRI), Seoul 04420, South Korea
Hyunjun Ahn, Department of Functional Genomics, University of Science and Technology KRIBB School, Deajeon 34113, South Korea
Won Ju Jung, 97.7 Beauty&Health (B&H) Clinics, Seoul 04420, South Korea
Author contributions: Ahn H, Lee SY, Jung WJ, and Lee KH designed the reports; Ahn H and Jung WJ collected the patients’ clinical data; Ahn H, Lee SY, and Jung WJ analyzed the data; Ahn H wrote the manuscript; Lee KH provided professional advice and revised the manuscript; all authors issued final approval for the version to be submitted.
Informed consent statement: The patients involved in this study gave their written informed consent authorizing disclosure of protected health information.
Conflict-of-interest statement: All authors have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kye-Ho Lee, PhD, bio Beauty&Health Company (bBHC) - Stem Cell Treatment & Research Institute (STRI), 72 UN village-gil Yongsan-gu, Seoul 04420, South Korea. sylee@stc365.com
Received: January 8, 2021
Peer-review started: January 8, 2021
First decision: February 12, 2021
Revised: February 24, 2021
Accepted: March 25, 2021
Article in press: March 25, 2021
Published online: May 26, 2021
Processing time: 123 Days and 9 Hours
Core Tip

Core Tip: Previous studies demonstrated that transplantation of mesenchymal stem cells (MSCs) was effective in treating autoimmune diseases. Alopecia areata (AA) and its related diseases are a representative autoimmune disease. In this case study, we used allogenic, minimally manipulated umbilical cord MSCs for the successful treatment of AA and alopecia universalis. This is the first report of using minimally manipulated umbilical cord MSCs to treat AA and related diseases.