Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 26, 2021; 9(15): 3623-3630
Published online May 26, 2021. doi: 10.12998/wjcc.v9.i15.3623
Subchondral bone as a novel target for regenerative therapy of osteochondritis dissecans: A case report
Sheng-Yang Zhang, Hui-Hui Xu, Miao-Miao Xiao, Jing-Jing Zhang, Qiang Mao, Bang-Jian He, Pei-Jian Tong
Sheng-Yang Zhang, Hui-Hui Xu, Jing-Jing Zhang, Institute of Orthopedics and Traumatology, The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Miao-Miao Xiao, The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Qiang Mao, Bang-Jian He, Pei-Jian Tong, Department of Orthopedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China
Author contributions: Zhang SY, Xu HH, Xiao MM, and Zhang JJ collected the information, followed the patient, and wrote the paper; Mao Q and He BJ revised the paper; Tong PJ was the patient’s orthopedic surgeon and performed the surgery; all authors read and approved the final manuscript.
Informed consent statement: The patient provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Pei-Jian Tong, MD, Chief Doctor, Professor, Department of Orthopedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China. tongpeijian@163.com
Received: January 5, 2021
Peer-review started: January 5, 2021
First decision: January 17, 2021
Revised: January 28, 2021
Accepted: March 3, 2021
Article in press: March 3, 2021
Published online: May 26, 2021
Processing time: 126 Days and 7.5 Hours
Core Tip

Core Tip: Osteochondritis dissecans is a relatively rare disease, and we used an unreported treatment that focused on subchondral bone as a novel target for implantation using peripheral blood stem cells. Magnetic resonance imaging at 4 mo postoperatively showed repair of both cartilage and subchondral bone, and the patient's knee function and pain improved.