Retrospective Cohort Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 26, 2021; 9(15): 3531-3545
Published online May 26, 2021. doi: 10.12998/wjcc.v9.i15.3531
Critical prognostic value of the log odds of negative lymph nodes/tumor size in rectal cancer patients
Jie-Bin Xie, Yue-Shan Pang, Xun Li, Xiao-Ting Wu
Jie-Bin Xie, Xiao-Ting Wu, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Jie-Bin Xie, Xun Li, Department of Gastrointestinal Surgery, Affiliated Hospital of North Sichuan Medical College China, Nanchong 637200, Sichuan Province, China
Yue-Shan Pang, Department of Geriatrics, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong 637200, Sichuan Province, China
Author contributions: Xie JB performed design, data collection, analysis, and drafting of manuscript; Pang YS performed design, data collection, and analysis; Li X performed design, data collection, and review; Wu XT performed design, analysis, review and editing; all authors read and approved the final version of the manuscript.
Supported by Cooperative Fund of Nanchong Government and North Sichuan Medical College, No. 18SXHZ0357.
Institutional review board statement: This study was exempted from Institutional Review Board approval, in view of the SEER’s use of unidentifiable patient information. Due to the strict register-based nature of the study, informed consent was waived. We also received permission to obtain research data from the SEER database, No. 11112-Nov2019.
Informed consent statement: Patients were not required to provide informed consent for the study because the analysis used anonymous clinical data.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Ting Wu, MD, PhD, Chief Doctor, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan Province, China. wxt1@medmail.com.cn
Received: November 12, 2020
Peer-review started: November 12, 2020
First decision: December 24, 2020
Revised: January 2, 2021
Accepted: March 10, 2021
Article in press: March 10, 2021
Published online: May 26, 2021
Processing time: 180 Days and 6.7 Hours
Core Tip

Core Tip: Log odds of negative lymph nodes/tumor size (LONS) was defined as the log of the ratio between negative lymph node count and the tumor size and has been first reported as a survival predictive tool in our study. Univariate and multivariate analyses confirmed LONS as an independent prognostic factor for stage I to III rectal cancer. The X-tile program demonstrated that the optimal cutoff was -0.8. Stratified analysis and Kaplan-Meier curves showed a significant improvement in the 10-year cancer-specific survival and overall survival in the high LONS group independent of clinicopathological factors.