Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 6, 2021; 9(13): 3194-3199
Published online May 6, 2021. doi: 10.12998/wjcc.v9.i13.3194
Association between scrub typhus encephalitis and diffusion tensor tractography detection of Papez circuit injury: A case report
Hyeok Gyu Kwon, Jeong-Hee Yang, Jee-Hyun Kwon, Dongseok Yang
Hyeok Gyu Kwon, Department of Physical Therapy, College of Health Science, Eulji University, Sanseong-daero 13135, Gyeonggi-do, South Korea
Jeong-Hee Yang, Department of Plastic Surgery, Biomedical Research Institute, Seoul National University Hospital, Jongno-gu 03080, Seoul, South Korea
Jee-Hyun Kwon, Department of Neurology, University of Ulsan College of Medicine, Ulsan University Hospital, Dong-gu 44033, Ulsan, South Korea
Dongseok Yang, Department of Physical Medicine and Rehabilitation, University of Ulsan College of Medicine, Ulsan University Hospital, Dong-gu 44033, Ulsan, South Korea
Author contributions: Yang D designed the report, collected the patient’s clinical data, and wrote the paper; Kwon HG provided the conceptualization and methodology, and analyzed the images and imaging-related information; Yang JH reviewed and revised the paper; Kwon JH reviewed the images and revised the paper.
Supported by National Research Foundation of Korea funded by the Ministry of Education, No. 2013R1A1A4A01013178.
Informed consent statement: Informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016) and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dongseok Yang, MD, PhD, Full Professor, Department of Physical Medicine and Rehabilitation, University of Ulsan College of Medicine, Ulsan University Hospital, 877 Bangeojin sunhwando-ro, Dong-gu 44033, Ulsan, South Korea. fnew11@gmail.com
Received: December 21, 2020
Peer-review started: December 21, 2020
First decision: December 30, 2020
Revised: January 22, 2021
Accepted: March 10, 2021
Article in press: March 10, 2021
Published online: May 6, 2021
Processing time: 122 Days and 10.9 Hours
Core Tip

Core Tip: Scrub typhus is one of the most common causes of acute encephalitis in endemic countries. It is still debated whether white matter (WM) is injured in the encephalitis of the scrub typhus. Diffusion tensor tractography allows us to investigate the integrity of WM three-dimensionally. The Papez circuit consists mainly of the WM and is known to play a critical role in cognition. Using a diffusion tensor tractography, we detected the injury of the Papez circuit in a patient with cognitive impairment following encephalitis of scrub typhus 23 years ago.