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World J Clin Cases. May 6, 2021; 9(13): 2969-2982
Published online May 6, 2021. doi: 10.12998/wjcc.v9.i13.2969
Immunotherapy for pancreatic cancer
Jai Hoon Yoon, Ye-Ji Jung, Sung-Hoon Moon
Jai Hoon Yoon, Department of Internal Medicine, Hanyang University College of Medicine, Seoul 04763, South Korea
Ye-Ji Jung, Department of Internal Medicine, Hallym University, Anyang 14068, South Korea
Sung-Hoon Moon, Department of Internal Medicine, University of Hallym College of Medicine, Hallym University Sacred Heart Hospital, Anyang 14068, South Korea
Author contributions: Yoon JH performed the drafting of the writing and performed data analysis and prepared tables; Jung YJ performed collection and analysis of data; Moon SH performed the majority of the writing, prepared the figures and tables.
Conflict-of-interest statement: The authors have no potential conflicts of interest. The authors alone are responsible for the content and writing of the paper.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sung-Hoon Moon, MD, PhD, Associate Professor, Department of Internal Medicine, University of Hallym College of Medicine, Hallym University Sacred Heart Hospital, 22 Gwanpyeong-ro 170-gil, Dongan-gu, Anyang 14068, South Korea. endomoon@hallym.or.kr
Received: January 4, 2021
Peer-review started: January 4, 2021
First decision: January 23, 2021
Revised: February 3, 2021
Accepted: March 9, 2021
Article in press: March 9, 2021
Published online: May 6, 2021
Core Tip

Core Tip: This review article addressed the role of immune cells in the development of pancreatic cancer, the tumor microenvironment, the cancer immunity cycle, the mechanisms and efficacies of immunotherapeutic drugs in pancreatic cancer, and the response criteria for use in trials aimed at testing immunotherapeutics. The strength of this article includes 2 characteristic tables for basic mechanisms and clinical outcomes related with pancreatic cancer immunotherapy.