Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 16, 2021; 9(11): 2611-2618
Published online Apr 16, 2021. doi: 10.12998/wjcc.v9.i11.2611
Eltrombopag-related renal vein thromboembolism in a patient with immune thrombocytopenia: A case report
Cen Wu, Xiao-Ming Zhou, Xiao-Dong Liu
Cen Wu, Xiao-Ming Zhou, Department of Respiratory and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Xiao-Dong Liu, Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Wu C and Zhou XM were responsible for the diagnosis and treatment of the patient; Wu C contributed to the data collection and patient follow-up and wrote the manuscript; all authors have read and approved the final manuscript.
Supported by The Natural Science Funding Guidance Project of Liaoning Province, No. 2018011494-301; and 345 Talent Program of Shengjing Hospital, China Medical University.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors of this paper have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Dong Liu, MD, Clinical Pharmacist, Department of Pharmacy, Shengjing Hospital of China Medical University, No. 36 San Hao Street, Shenyang 110004, Liaoning Province, China. liuxdcmu@163.com
Received: December 9, 2020
Peer-review started: December 9, 2020
First decision: December 24, 2020
Revised: January 9, 2021
Accepted: February 22, 2021
Article in press: February 22, 2021
Published online: April 16, 2021
Processing time: 109 Days and 20.2 Hours
Core Tip

Core Tip: Eltrombopag is a thrombopoietin receptor agonist carrying an increased risk of treatment-related thromboembolism. Reports implicating both venous and arterial thromboses have appeared in the medical literature. Herein, we describe a patient with immune thrombocytopenia but no signs of nephropathy who developed renal vein thrombosis and pulmonary embolism while receiving eltrombopag. During subsequent anticoagulant treatment, the renal vein thrombus spontaneously resolved, restoring venous circulation. A rapid upsurge in platelets (as opposed to their absolute count) may be the chief determinant of such thrombotic events during cytopenic downturns.