Xu ZG, Li WL, Wang X, Zhang SY, Zhang YW, Wei X, Li CD, Zeng P, Luan SD. Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits in a young woman: A case report. World J Clin Cases 2021; 9(10): 2357-2366 [PMID: 33869614 DOI: 10.12998/wjcc.v9.i10.2357]
Corresponding Author of This Article
Shao-Dong Luan, PhD, Chief Doctor, Department of Nephrology, Shenzhen Longhua District Central Hospital, No. 187 Guanlan Road, Shenzhen 518110, Guangdong Province, China. szkidney3@163.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Zi-Gan Xu, Wei-Long Li, Xi Wang, Shu-Yuan Zhang, Ying-Wei Zhang, Xing Wei, Chun-Di Li, Ping Zeng, Shao-Dong Luan, Department of Nephrology, Shenzhen Longhua District Central Hospital, Shenzhen 518110, Guangdong Province, China
Author contributions: Xu ZG reviewed the literature and contributed to manuscript drafting; Li WL, Wang X, Zhang SY, Zhang YW, Li CD, and Zeng P collected the information from the patient; Wei X and Luan SD were surgeons for biopsy and revised the manuscript; Luan SD supervised the study; all authors read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shao-Dong Luan, PhD, Chief Doctor, Department of Nephrology, Shenzhen Longhua District Central Hospital, No. 187 Guanlan Road, Shenzhen 518110, Guangdong Province, China. szkidney3@163.com
Received: November 11, 2020 Peer-review started: November 11, 2020 First decision: December 21, 2020 Revised: January 2, 2021 Accepted: January 27, 2021 Article in press: January 27, 2021 Published online: April 6, 2021
Core Tip
Core Tip: Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits (PGNMID) is a rare renal disease whose pathogenesis is not fully understood. Due to its complexity, this disease is easy to misdiagnose. We report the case of a young female patient with gross hematuria and foamy urine. Renal biopsy in another hospital suggested mesangial proliferating glomerulonephritis (MsPGN). Her condition did not improve significantly after treatment with glucocorticoids and immuno-suppressants. Recently, repeated renal biopsy at our hospital suggested PGNMID. This case suggests that although PGNMID often occurs in middle-aged and elderly individuals, it cannot be readily excluded in young people with the pathological type of membranoproliferative glomerulonephritis or MsPGN, even when immunofixation electrophoresis is negative. An accurate diagnosis at the earliest stage may minimize the use of glucocorticoids and immunosuppressants.
