Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 6, 2021; 9(10): 2312-2319
Published online Apr 6, 2021. doi: 10.12998/wjcc.v9.i10.2312
Changes in sleep parameters following biomimetic oral appliance therapy: A case report
G Dave Singh, Shamshudin Kherani
G Dave Singh, Institute of Craniofacial Sleep Medicine, Vivos Therapeutics, Inc., Highlands Ranch, CO 80129, United States
Shamshudin Kherani, Dental Clinic, Kherani Dental at Aspen, Calgary T3H0N6, Canada
Author contributions: Singh GD, analyzed and interpreted the findings, reviewed the literature, contributed to manuscript drafting and is responsible for intellectual content; Kherani S was the patient’s dentist, contributed to manuscript drafting and is responsible for intellectual content. Both authors issued final approval for the version to be submitted.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no conflict of interest except that Professor G. Dave Singh DMD PhD DDSc is Founder and Chief Medical Officer of Vivos Therapeutics, Inc.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: G Dave Singh, DMD, PhD, DDSc, Professor, Institute of Craniofacial Sleep Medicine, Vivos Therapeutics, Inc., 9137 S Ridgeline Blvd # 135, Highlands Ranch, CO 80129, United States. drsingh@drdavesingh.com
Received: October 15, 2020
Peer-review started: October 15, 2020
First decision: December 28, 2020
Revised: January 4, 2021
Accepted: February 19, 2021
Article in press: February 19, 2021
Published online: April 6, 2021
Core Tip

Core Tip: Mandibular advancement devices (MADs) are considered to be a first line therapy in adult cases of mild to moderate obstructive sleep apnea that are unable to comply with continuous positive airway pressure. However, both MADs and continuous positive airway pressure represent a lifetime of therapy and there is a risk that the underlying condition may worsen over time as the patient undergoes ageing. In contrast, biomimetic oral appliance therapy differs from MADs since it attempts to mimic normal craniofacial growth and development. The primary target of biomimetic oral appliance therapy is the nasomaxillary complex, which is non-surgically corrected even in adult cases followed by re-coordination with the mandible.