Case Report
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 6, 2021; 9(1): 224-231
Published online Jan 6, 2021. doi: 10.12998/wjcc.v9.i1.224
Atypical adult-onset Still’s disease with an initial and sole manifestation of liver injury: A case report and review of literature
Fan Yu, Shao-You Qin, Chang-Yu Zhou, Lu Zhao, Yan Xu, Er-Na Jia, Jiang-Bin Wang
Fan Yu, Shao-You Qin, Chang-Yu Zhou, Yan Xu, Er-Na Jia, Jiang-Bin Wang, Department of Gastroenterology and Hepatology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China
Lu Zhao, Department of Digestive, Heze Municipal Hospital, Heze 274000, Shandong Province, China
Author contributions: Yu F, Zhou CY, Zhao L and Wang JB were members of the patient’s medical team, reviewed the literature and contributed to manuscript drafting; Xu Y and Jia EN reviewed the literature and contributed to manuscript drafting; Qin SY performed data interpretation and contributed to manuscript drafting; Qin SY and Wang JB were responsible for the revision of the manuscript for important intellectual content; all authors issued final approval for the version to be submitted; Yu F and Qin SY contributed equally to the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jiang-Bin Wang, PhD, Chief Physician, Department of Gastroenterology and Hepatology, China-Japan Union Hospital of Jilin University, No. 126 Xiantai Street, Changchun 130033, Jilin Province, China. jiangbin@jlu.edu.cn
Received: August 17, 2020
Peer-review started: August 17, 2020
First decision: October 18, 2020
Revised: October 21, 2020
Accepted: November 4, 2020
Article in press: November 4, 2020
Published online: January 6, 2021
Core Tip

Core Tip: Liver involvement in the form of increased hepatic enzymes and bilirubin is common in adult-onset Still's disease (AOSD). Herein, we presented a patient with relapsed AOSD with hepatic involvement as an initial and sole manifestation responding well to glucocorticoid treatment. This case highlights that hepatic involvement as an initial and sole manifestation could be a pattern of relapsed AOSD. The diagnosis of AOSD should be considered in the case of nonresolving liver injury after the exclusion of common etiologies for liver diseases. A liver biopsy can be useful for the differential diagnosis of liver injury associated with AOSD.