Meta-Analysis
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 6, 2021; 9(1): 133-147
Published online Jan 6, 2021. doi: 10.12998/wjcc.v9.i1.133
Polymerase chain reaction-based tests for detecting Helicobacter pylori clarithromycin resistance in stool samples: A meta-analysis
Ren-Jie Gong, Can-Xia Xu, Huan Li, Xiao-Ming Liu
Ren-Jie Gong, Can-Xia Xu, Huan Li, Xiao-Ming Liu, Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China
Author contributions: Gong RJ conceived and designed the study, acquired, analyzed and interpreted the data, and drafted and revised the article; Xu CX acquired, analyzed, and interpreted the data and revised the article; Li H acquired, analyzed, and interpreted the data; Liu XM interpreted the data, critically revised the article, and approved the final version.
Supported by “New Xiangya Talent Projects” of The Third Xiangya Hospital of Central South University, No. JY201710.
Conflict-of-interest statement: The authors declare that they have no competing interests.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Ming Liu, MD, Chief Doctor, Department of Gastroenterology, The Third Xiangya Hospital of Central South University, No. 138 Tongzipo Street, Changsha 410013, Hunan Province, China. liuxiaoming26@163.com
Received: August 6, 2020
Peer-review started: August 6, 2020
First decision: November 3, 2020
Revised: November 7, 2020
Accepted: November 14, 2020
Article in press: November 14, 2020
Published online: January 6, 2021
Processing time: 147 Days and 21.7 Hours
Core Tip

Core Tip: No consensus is available in the literature about the reliability of polymerase chain reaction (PCR)-based tests for detecting Helicobacter pylori (H. pylori) clarithromycin resistance in stool samples. This is the first meta-analysis deciphering these methods based on the numbers of true-positive, false-positive, false-negative, and true-negative test results. Our results show that PCR-based approaches on stool samples have high diagnostic accuracy for detecting H. pylori clarithromycin resistance.