Case Report
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 6, 2020; 8(9): 1651-1655
Published online May 6, 2020. doi: 10.12998/wjcc.v8.i9.1651
Seroconversion of HBsAG coincides with hepatitis A super-infection: A case report
Claudia Beisel, Marylyn M Addo, Julian Schulze zur Wiesch
Claudia Beisel, Marylyn M Addo, Julian Schulze zur Wiesch, Department of Internal Medicine, Division of Infectious Disease, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany
Claudia Beisel, Marylyn M Addo, Julian Schulze zur Wiesch, German Center for Infection Research, Hamburg 20251, Germany
Author contributions: Beisel C was the patient’s doctor in charge and was responsible for collecting medical history, reviewing the literature, and drafting the paper; Schulze zur Wiesch J was the patient’s doctor in charge; Schulze zur Wiesch J and Addo MM reviewed the literature and made contribution to revising the manuscript; all authors issued final approval for the version to be submitted.
Informed consent statement: In the presented case blood tests led to our diagnosis. No invasive diagnostic procedures were performed; accordingly no informed consent was required.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Julian Schulze zur Wiesch, MD, Assistant Professor, Department of Internal Medicine, Division of Infectious Disease, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg 20251, Germany. German Center for Infection Research (DZIF), Hamburg, Germany. j.schulze-zur-wiesch@uke.de
Received: February 5, 2020
Peer-review started: February 5, 2020
First decision: February 27, 2020
Revised: March 26, 2020
Accepted: April 17, 2020
Article in press: April 17, 2020
Published online: May 6, 2020
Processing time: 85 Days and 2.9 Hours
Core Tip

Core tip: In patients with chronic hepatitis B virus (HBV) infection, super-infection with other hepatotropic viruses can lead severe liver diseases with acute on chronic liver failure, underlying the need to check for a complete hepatitis A virus (HAV) vaccination status. Here, we present an unvaccinated patient with HBV related liver cirrhosis who experienced an acute HAV super-infection. HAV infection was spontaneously cleared without signs of acute liver failure. Furthermore, most likely to an unspecific immunological response functional cure of HBV was observed (seroconversion of HBsAg to anti-HBs).