Case Control Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Mar 6, 2020; 8(5): 874-886
Published online Mar 6, 2020. doi: 10.12998/wjcc.v8.i5.874
Significance of 125I radioactive seed implantation on growth differentiation factor and programmed death receptor-1 during treatment of oral cancer
Gang Xue, Yao Feng, Jia-Bin Li
Gang Xue, Department II of Prosthodontics, The Second Affiliated Hospital of Jiamusi University, Jiamusi 154000, Heilongjiang Province, China
Yao Feng, Department I of Endodontics, The Second Affiliated Hospital of Jiamusi University, Jiamusi 154000, Heilongjiang Province, China
Jia-Bin Li, Department II of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Jiamusi University, Jiamusi 154000, Heilongjiang Province, China
Author contributions: Xue G designed the research and performed the research; Feng Y analyzed the data; Li JB wrote the paper. Xue G and Feng Y contributed equally to this work.
Supported by Heilongjiang Provincial Health and Family Planning Commission Research Project, No. 2017-413.
Institutional review board statement: This study was reviewed and approved by the Second Affiliated Hospital of Jiamusi University Ethics Committee.
Informed consent statement: All patients in our study provided informed consent.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jia-Bin Li, MSc, Attending doctor, Department II of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Jiamusi University, No.522, Hongqi Street, Jiamusi 154000, Heilongjiang Province, China. jiping199210@126.com
Received: November 19, 2019
Peer-review started: November 19, 2019
First decision: December 4, 2019
Revised: December 12, 2019
Accepted: January 8, 2020
Article in press: January 8, 2020
Published online: March 6, 2020
Core Tip

Core tip: 125I radioactive seed implantation for oral cancer (OC) shows clinical efficacy and reduces the recurrence rate in patients, thus has marked potential in clinical applications. The detection of growth differentiation factor 11 and programmed death receptor-1 in patients during treatment demonstrated that this therapy has good predictive value for treatment efficacy and recurrence in OC patients, and may be potential targets for future OC treatment.