Clinical and Translational Research
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 26, 2020; 8(4): 658-669
Published online Feb 26, 2020. doi: 10.12998/wjcc.v8.i4.658
Identification of key genes and pathways in gastric signet ring cell carcinoma based on transcriptome analysis
Zi-Tong Zhao, Yang Li, Hong-Yu Yuan, Fu-Hai Ma, Yong-Mei Song, Yan-Tao Tian
Zi-Tong Zhao, Hong-Yu Yuan, Yong-Mei Song, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Yang Li, Fu-Hai Ma, Yan-Tao Tian, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Zhao ZT and Li Y contributed equally to this work; Zhao ZT, Li Y, Yuan HY, Ma FH, Song YM, and Tian YT contributed to the design of the study and the writing of the manuscript; all the authors reviewed and approved the final version to be published.
Supported by National Key R&D Program of China, No. 2018YFC1313101; Wu Jieping Medical Foundation, No. 320.6750.15276.
Institutional review board statement: This study was approved by the institutional review board of the National Cancer Center of China.
Informed consent statement: The institutional review board of the National Cancer Center of China waived informed consent due to the retrospective nature of this research.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yan-Tao Tian, MD, Professor, Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. tyt67@163.com
Received: January 2, 2020
Peer-review started: January 2, 2020
First decision: January 19, 2020
Revised: January 20, 2020
Accepted: February 15, 2020
Article in press: February 15, 2020
Published online: February 26, 2020
Processing time: 55 Days and 8.4 Hours
Core Tip

Core tip: Gastric signet ring cell carcinoma (GSRCC) is one of the most malignant tumors. It has the features of high invasiveness, rapid progression, and resistance to chemotherapy. However, systematic analyses of mRNAs have not yet been performed for GSRCC. We have identified the potential key genes and pathways of GSRCC, and these hub genes and pathways could be diagnostic markers and therapeutic targets for GSRCC.