Nomura E, Kayano H, Machida T, Izumi H, Yamamoto S, Sugawara A, Mukai M, Hasebe T. Neoadjuvant chemoradiotherapy for locally advanced gastric cancer with bulky lymph node metastasis: Five case reports. World J Clin Cases 2020; 8(18): 4177-4185 [PMID: 33024776 DOI: 10.12998/wjcc.v8.i18.4177]
Corresponding Author of This Article
Eiji Nomura, MD, PhD, Doctor, Professor, Surgeon, Department of Gastroenterological and General Surgery, Tokai University Hachioji Hospital, 1838 Ishikawa-machi, Hachioji 192-0032, Tokyo, Japan. nomura@hachioji-hosp.tokai.ac.jp
Research Domain of This Article
Surgery
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Eiji Nomura, Hajime Kayano, Takashi Machida, Hideki Izumi, Soichiro Yamamoto, Masaya Mukai, Department of Gastroenterological and General Surgery, Tokai University Hachioji Hospital, Hachioji 192-0032, Tokyo, Japan
Akitomo Sugawara, Terumitsu Hasebe, Department of Radiology, Tokai University Hachioji Hospital, Hachioji 192-0032, Tokyo, Japan
Author contributions: Nomura E collected the patients’ clinical data and drafted the manuscript; Sugawara A, Nomura E, Kayano H and Yamamoto S helped in the management of the patients; Machida T, Izumi H and Mukai M collected the patients’ clinical data; Hasebe T made revisions and supervised the study; all authors read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from all five patients for publication of this report and any accompanying images.
Conflict-of-interest statement: No conflict of interest exists in relation to this manuscript.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Eiji Nomura, MD, PhD, Doctor, Professor, Surgeon, Department of Gastroenterological and General Surgery, Tokai University Hachioji Hospital, 1838 Ishikawa-machi, Hachioji 192-0032, Tokyo, Japan. nomura@hachioji-hosp.tokai.ac.jp
Received: June 29, 2020 Peer-review started: June 29, 2020 First decision: July 24, 2020 Revised: August 1, 2020 Accepted: August 26, 2020 Article in press: August 26, 2020 Published online: September 26, 2020 Processing time: 84 Days and 21.1 Hours
Core Tip
Core Tip: Cancer patients at very high risk are difficult to treat with powerful preoperative chemotherapies, and extensive lymph node dissection might not always be an option. If radiation therapy is found to be safe and effective in these patients, it might increase the therapeutic options available for advanced gastric cancer. Preoperative intensity modulated radiation therapy together with a regimen of concomitant chemotherapy with tegafur/gimeracil/oteracil was delivered to five patients with clinical Stage III gastric cancer, bulky lymph node metastasis, and adjacent organ invasion. All patients subsequently underwent no residual tumor resection. Slightly reduced doses of neoadjuvant chemoradiotherapy might be useful and safe for patients with locally advanced gastric cancer.
