Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 26, 2020; 8(18): 4051-4058
Published online Sep 26, 2020. doi: 10.12998/wjcc.v8.i18.4051
Intratympanic dexamethasone injection for sudden sensorineural hearing loss in pregnancy
Yan-Lu Lyu, Fan-Qian Zeng, Zhou Zhou, Min Yan, Wei Zhang, Ming Liu, Zhao-Yang Ke
Yan-Lu Lyu, Fan-Qian Zeng, Zhou Zhou, Min Yan, Wei Zhang, Ming Liu, Zhao-Yang Ke, Department of Otorhinolaryngology–Head and Neck Surgery, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong Province, China
Author contributions: Lyu YL, Zeng FQ and Ke ZY conducted the studies, collected the data, and drafted the manuscript; Zhou Z, Yan M, Zhang W and Liu M participated in the study design and patient follow-up, and helped draft the manuscript; all authors read and approved the final version of the manuscript.
Supported by the Health and Family Planning Commission of Shenzhen Municipality, No. SZXJ2017065.
Institutional review board statement: This study was approved by the Committee of our Hospital.
Informed consent statement: All the patients were fully informed of the treatment modalities and the associated risks of medication or medical observations. All patients signed informed consent forms before they were enrolled in research.
Conflict-of-interest statement: The authors declare that there is no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Zhao-Yang Ke, MD, Chief Doctor, Department of Otorhinolaryngology–Head and Neck Surgery, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), No. 1017 North Dongmen Road, Luohu District, Shenzhen 518020, Guangdong Province, China. szrmebh@outlook.com
Received: May 11, 2020
Peer-review started: May 11, 2020
First decision: June 7, 2020
Revised: June 23, 2020
Accepted: August 12, 2020
Article in press: August 12, 2020
Published online: September 26, 2020
Processing time: 133 Days and 13.9 Hours
Core Tip

Core Tip: Sudden sensorineural hearing loss (SSNHL)rarely happens in pregnant women. The lack of understanding and guidelines in this condition has caused treatment dilemma. We retrospectively analyzed our experience with intratympanic dexamethasone injections for patients with sudden deafness during pregnancy and found out that the treatment group demonstrated a significantly better hearing threshold and greater improvement than control group after a total dose of 10 mg dexamethasone. Thus, we suggest that intratympanic dexamethasone injections should be applied as a safe and effective therapy for SSNHL during pregnancy.