Case Control Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 26, 2020; 8(18): 4017-4021
Published online Sep 26, 2020. doi: 10.12998/wjcc.v8.i18.4017
Relationship between granulomatous lobular mastitis and methylene tetrahydrofolate reductase gene polymorphism
Qing-Ran Lei, Xin Yang, Chun-Mei Miao, Jin-Chang Wang, Yue Yang
Qing-Ran Lei, Xin Yang, Chun-Mei Miao, Jin-Chang Wang, Yue Yang, Department of Breast, The First People's Hospital of Kunming, Kunming 650031, Yunnan Province, China
Author contributions: Lei QR, Yang X, Miao CM, Wang JC and Yang Y wrote, edited and proofread the manuscript.
Supported by the Xishan District Science and Technology Plan Project of Kunming.
Institutional review board statement: The study was approved by Ethics Committee of The First Hospital of Kunming.
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: The authors declare that there is no conflict of interest.
Data sharing statement: No additional data available.
STROBE statement: The manuscript has been prepared and revised according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yue Yang, PhD, Chief Physician, Department of Breast, The First People's Hospital of Kunming, No. 504 Qingnian Road, Kunming 650031, Yunnan Province, China. yangyue_2018@sina.com
Received: June 16, 2020
Peer-review started: June 16, 2020
First decision: July 25, 2020
Revised: August 5, 2020
Accepted: August 15, 2020
Article in press: August 15, 2020
Published online: September 26, 2020
Processing time: 97 Days and 23.6 Hours
Core Tip

Core Tip: Methylene tetrahydrofolate reductase (MTHFR) gene polymorphism is associated with several diseases. It was reported that mutations in MTHFR-C677T is associated with breast cancer. We tested the association between MTHFR gene polymorphism and granulomatous lobular mastitis in patients with this disease. The results supported our hypothesis that MTHFR C677T is a susceptibility factor that may influence the occurrence of granulomatous lobular mastitis.