Case Report
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2020; 8(16): 3560-3566
Published online Aug 26, 2020. doi: 10.12998/wjcc.v8.i16.3560
Clinical laboratory investigation of a patient with an extremely high D-dimer level: A case report
Han-Xiao Sun, Hong Ge, Zhong-Qing Xu, Hui-Ming Sheng
Han-Xiao Sun, Hong Ge, Hui-Ming Sheng, Department of Laboratory Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
Zhong-Qing Xu, Department of General Practice, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
Author contributions: Sun HX and Ge H contributed equally to this work; Sun HX, Xu ZQ and Sheng HM prepared the case and contributed to manuscript drafting; Sun HX and Ge H analyzed the case; Sheng HM reviewed the literature and supervised the study; all authors gave final approval for the version to be submitted.
Supported by the National Natural Science Foundation of China, No. 81672083 and No. 81702071.
Informed consent statement: This study was conducted in accordance with the Helsinki Declaration and with our Ethical Committee’s approval.
Conflict-of-interest statement: All authors state that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hui-Ming Sheng, MD, PhD, Professor, Department of Laboratory Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No. 1111 Xianxia Road, Shanghai 200336, China. hmsheng@shsmu.edu.cn
Received: April 14, 2020
Peer-review started: April 21, 2020
First decision: May 21, 2020
Revised: June 2, 2020
Accepted: July 22, 2020
Article in press: July 22, 2020
Published online: August 26, 2020
Processing time: 126 Days and 4.3 Hours
Core Tip

Core tip: Heterophilic antibodies should be considered while elevated D-dimer value is not in conformity with clinical evidence. We will keep on doing subsequent serial monitoring of D-dimer values with anti-virus therapy and more research needs to be done to verify the exact fragment to improve the D-dimer test in the near future.