Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2020; 8(16): 3493-3502
Published online Aug 26, 2020. doi: 10.12998/wjcc.v8.i16.3493
Value of miR-1271 and glypican-3 in evaluating the prognosis of patients with hepatocellular carcinoma after transcatheter arterial chemoembolization
Zheng Guo, Jing Wang, Li Li, Rong Liu, Jin Fang, Bin Tie
Zheng Guo, Li Li, Rong Liu, Jin Fang, Bin Tie, Department of Interventional Medicine, the First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
Jing Wang, Emergency Department, the First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
Author contributions: All authors helped to perform the research; Guo Z wrote the manuscript; Wang J performed the procedures; Li L and Liu R analyzed and interpreted the data; Fang J designed the research; Tie B collected the materials and clinical data.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the First Hospital of Lanzhou University.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent. For full disclosure, the details of the study are published on the home page of Lanzhou University.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Bin Tie, MAMS, Attending Doctor, Department of Interventional Medicine, The First Hospital of Lanzhou University, No. 1 Donggang West Road, Lanzhou 730000, Gansu Province, China. tie12bin@163.com
Received: May 26, 2020
Peer-review started: May 26, 2020
First decision: June 13, 2020
Revised: June 24, 2020
Accepted: July 23, 2020
Article in press: July 23, 2020
Published online: August 26, 2020
Processing time: 91 Days and 0.5 Hours
Core Tip

Core tip: The results of this study show that the serum glypican-3 (GPC3) level in patients with hepatocellular carcinoma recurrence after transcatheter arterial chemoembolization is significantly higher than that in the remission group, and miR-1271 is significantly lower. The combined detection of serum GPC3 and miR-1271 has an important clinical reference value for evaluating the prognosis of hepatocellular carcinoma. Serum GPC3 and miR-1271 levels can help determine tumor recurrence and prognosis evaluation.