Clinical and Translational Research
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 26, 2020; 8(10): 1848-1858
Published online May 26, 2020. doi: 10.12998/wjcc.v8.i10.1848
Cross electro-nape-acupuncture ameliorates cerebral hemorrhage-induced brain damage by inhibiting necroptosis
Guo-Feng Cai, Zhong-Ren Sun, Zhe Zhuang, Hai-Chun Zhou, Shan Gao, Kai Liu, Li-Li Shang, Kun-Ping Jia, Xiu-Zhen Wang, Hui Zhao, Guo-Liang Cai, Wen-Li Song, Sheng-Nan Xu
Guo-Feng Cai, Hai-Chun Zhou, Kai Liu, Kun-Ping Jia, Xiu-Zhen Wang, Hanan Branch of Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150001, Heilongjiang Province, China
Guo-Feng Cai, Postdoctoral Research Station of Heilongjiang Academy of Traditional Chinese Medicine, Harbin 150001, Heilongjiang Province, China
Zhong-Ren Sun, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, Heilongjiang Province, China
Zhe Zhuang, Li-Li Shang, Hui Zhao, Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150000, Heilongjiang Province, China
Shan Gao, First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, Heilongjiang Province, China
Guo-Liang Cai, Wen-Li Song, Harbin Sport University, Harbin 150001, Heilongjiang Province, China
Sheng-Nan Xu, Graduate School of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, Heilongjiang Province, China
Author contributions: Cai GF, Xu SN, Sun ZR and Zhuang Z performed the majority of experiments and analyzed the data; Zhou HC and Gao S performed the molecular investigations; Liu K, Shang LL and Jia KP designed and coordinated the research; Wang XZ, Zhao H, Cai GL and Song WL wrote the paper; Cai GF and Sun ZR contributed equally to this work.
Supported by State Administration of Traditional Chinese Medicine of Heilongjiang Province, No. ZHY16-027; and Harbin Municipal Science and Technology Bureau-Youth Reserve Talent Project, No. 2017RAQXJ170.
Institutional animal care and use committee statement: This study was reviewed and approved by the Animal Use and Care Committee of Heilongjiang University of Chinese Medicine.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Kun-Ping Jia, MSc, Attending Doctor, Hanan Branch of Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, No. 26, Second Avenue, Pingfang District, Harbin 150001, Heilongjiang Province, China. jka3ih@163.com
Received: January 10, 2020
Peer-review started: January 10, 2020
First decision: February 20, 2020
Revised: March 1, 2020
Accepted: April 22, 2020
Article in press: April 22, 2020
Published online: May 26, 2020
Processing time: 135 Days and 21.9 Hours
Core Tip

Core tip: This study demonstrated that necroptosis existed in the brain of rats with cerebral hemorrhage (CH). Further examination revealed that receptor interacting protein kinase 1 (RIPK1) mediated necroptosis in CH, and cross electro-nape acupuncture (CENA) suppressed RIPK1 to ameliorate brain damage in rats with CH. Moreover, CENA inhibited inflammation in CH. Therefore, these results suggested a neuroprotective role of CENA by targeting RIPK1-mediated necroptosis in rats with CH.