Case Control Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 6, 2020; 8(1): 11-19
Published online Jan 6, 2020. doi: 10.12998/wjcc.v8.i1.11
Oncogenic role of Tc17 cells in cervical cancer development
Zun-Sheng Zhang, Ying Gu, Bing-Gang Liu, Hong Tang, Yu Hua, Jun Wang
Zun-Sheng Zhang, Ying Gu, Bing-Gang Liu, Hong Tang, Yu Hua, Jun Wang, Department of Obstetrics and Gynecology, Shanghai Seventh People’s Hospital, Shanghai 200120, China
Author contributions: Zhang ZS and Gu Y designed the research; Tang H and Hua Y performed the research; Liu BG analyzed the data; Wang J wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Shanghai Seventh People’s Hospital Ethics Committee.
Informed consent statement: All patients in our study provided informed consent.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Jun Wang, MSc, Attending Doctor, Department of Obstetrics and Gynecology, Shanghai Seventh People’s Hospital, No. 358, Datong Road, Gaoqiao Town, Pudong New Area, Shanghai 200120, China. wanchuang3069629@163.com
Received: October 7, 2019
Peer-review started: October 7, 2019
First decision: November 13, 2019
Revised: November 18, 2019
Accepted: November 30, 2019
Article in press: November 30, 2019
Published online: January 6, 2020
Processing time: 91 Days and 8.6 Hours
Core Tip

Core tip: Inflammation contributes to cancer development. In this study, it was found that cervical cancer-elicited inflammation increased Tc17-polarizing cytokine production, which attenuated cytotoxic CD8+ T cell development. The high level of interleukin-17 production by Tc17 cells led to CXCL12 upregulation and cancer cell migration. Consistent with the oncogenic role of Tc17 cells in cancer development, the ratio of cancer-infiltrating Tc17 cells was highly associated with poor prognosis in patients with cervical cancer. Thus, our data demonstrate that Tc17 cells can be induced in cervical cancers and serve as a meaningful index in the prognosis of patients with cervical cancer.