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World J Clin Cases. Apr 6, 2019; 7(7): 819-829
Published online Apr 6, 2019. doi: 10.12998/wjcc.v7.i7.819
Porphyromonas gingivalis and digestive system cancers
Ying Zhou, Guang-Hua Luo
Ying Zhou, Guang-Hua Luo, Comprehensive Laboratory, the Third Affiliated Hospital of Soochow University, Changzhou 213003, Jiangsu Province, China
Author contributions: Zhou Y prepared the manuscript; Luo GH critically revised the intellectual content and gave final approval of manuscript.
Supported by Changzhou High-Level Medical Talents Training Project, No: 2016ZCLJ002.
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to this study.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Guang Hua Luo, MD, PhD, Professor, Comprehensive Laboratory, the Third Affiliated Hospital, Soochow University, No. 185, Juqian Street, Changzhou 213003, Jiangsu Province, China. shineroar@163.com
Telephone: +86-519-68870619 Fax: +86-591-86621235
Received: December 28, 2018
Peer-review started: December 29, 2018
First decision: January 30, 2019
Revised: February 26, 2019
Accepted: March 11, 2019
Article in press: March 11, 2019
Published online: April 6, 2019
Processing time: 99 Days and 1.9 Hours
Core Tip

Core tip:Porphyromonas gingivalis (P. gingivalis) has been discovered in many digestive system cancers, such as oral squamous cell carcinoma, oesophageal squamous cell carcinoma, and pancreatic cancer. For the strong association between P. gingivalis and periodontal diseases, we also interpret how periodontal diseases push effects on digestive system tumours. This review also presents some preventions and possible treatments for these cancers associated with P. gingivalis infection. In addition, the mechanisms by which P. gingivalis affects the occurrence and development of carcinomas are covered, including immune evasion, tumourigenesis, inhibition of apoptosis and invasion of tumour cells.