Split-dose or hybrid nonsteroidal anti-inflammatory drugs and N-acetylcysteine therapy for prevention of post-retrograde cholangiopancreatography pancreatitis
Laura Pavel, Gheorghe Gh Bălan, Alexandra Nicorescu, Georgiana Emmanuela Gîlcă-Blanariu, Cătălin Sfarti, Ștefan Chiriac, Smaranda Diaconescu, Vasile Liviu Drug, Gheorghe Bălan, Gabriela Ștefănescu
Laura Pavel, Gheorghe Gh Bălan, Georgiana Emmanuela Gîlcă-Blanariu, Cătălin Sfarti, Ștefan Chiriac, Vasile Liviu Drug, Gheorghe Bălan, Gabriela Ștefănescu, Gastroenterology, “Grigore T. Popa” University of Medicine and Pharmacy, Iași 700115, România
Alexandra Nicorescu, Endocrinology, “Grigore T. Popa” University of Medicine and Pharmacy, Iași 700115, România
Smaranda Diaconescu, Department of Mother and Child Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iași 700115, România
Author contributions: Pavel L, Bălan GG, Gîlcă-Blanariu GE, Bălan G and Ștefănescu G, participated in the protocol design, identification and inclusion of candidates, collection of clinical information, and patient follow-up; Bălan GG, Sfarti C, Drug VL, Chiriac Ș band Bălan G performed the endoscopic interventions; Pavel L, Diaconescu S, Nicorescu A and Ștefănescu G participated in the protocol design and statistical analysis; all authors were involved in critical review of the results and approved the final manuscript.
Institutional review board statement: The Institutional Review Board of “Gr. T. Popa” University of Medicine and Pharmacy - Iași provided approval for this study (IRB No. 27/03/2017).
Clinical trial registration statement: This study is registered at ClinicalTrials.gov, registration number NCT03708458.
Informed consent statement: Consent was obtained from all the patients that were included in the study.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CONSORT 2010 statement: The CONSORT 2010 Statement was uploaded.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Smaranda Diaconescu, MD, PhD, Associate Professor, Department of Mother and Child Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universității str, Iași 700115, România.
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Received: October 30, 2018
Peer-review started: October 31, 2018
First decision: November 15, 2018
Revised: December 18, 2018
Accepted: December 21, 2018
Article in press: December 24, 2018
Published online: February 6, 2019
Processing time: 92 Days and 11.9 Hours
