Retrospective Cohort Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 6, 2019; 7(3): 260-269
Published online Feb 6, 2019. doi: 10.12998/wjcc.v7.i3.260
Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma
Henna K Söderström, Juha T Kauppi, Niku Oksala, Timo Paavonen, Leena Krogerus, Jari Räsänen, Tuomo Rantanen
Henna K Söderström, Juha T Kauppi, Jari Räsänen, Department of General Thoracic Surgery, Helsinki University Central Hospital, Helsinki 00029, Finland
Niku Oksala, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland
Niku Oksala, Department of Vascular Surgery, Tampere University Hospital, Tampere 33520, Finland
Timo Paavonen, Department of Pathology, Fimlab Laboratories and Department of Medicine and Life Sciences, University of Tampere, Tampere 33520, Finland
Leena Krogerus, Department of Pathology, Helsinki University Central Hospital, 00029 Helsinki 00029, Finland
Tuomo Rantanen, Department of Surgery, Kuopio University Hospital, Kuopio 70029, Finland
Tuomo Rantanen, Department of Surgery, Institute of Clinical Medicine, University of Eastern Finland, Kuopio 70029, Finland
Author contributions: All the authors contributed to this paper.
Institutional review board statement: The study has been approved by the Ethics Committee at Helsinki University Central Hospital.
Informed consent statement: Because of retrospective study signed informed consent form is not needed. However, Helsinki University Hospital has given permission to conduct this study.
Conflict-of-interest statement: Authors have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Tuomo Rantanen, MD, PhD, Professor, Department of Surgery, Kuopio University Hospital, Box 100, Kuopio 70029, Finland. tuomo.rantanen@kuh.fi
Telephone: +358-50-4028461 Fax: +358-17-173 599
Received: November 19, 2018
Peer-review started: November 19, 2018
First decision: December 5, 2018
Revised: December 21, 2018
Accepted: December 29, 2018
Article in press: December 30, 2018
Published online: February 6, 2019
Processing time: 72 Days and 14.7 Hours
Core Tip

Core tip: Heat shock proteins (HSPs) are classified according to molecular weight into distinct protein families, and they are present in all human cells. Overexpression of HSPs is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Because of the poor prognosis of esophageal adenocarcinoma (EAC), it would be valuable to find new biomarkers for the development of cancer treatments. We conducted the present study to analyze the expression of HSP27 and HSP70, and their association with survival, in patients with EAC.