Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 26, 2019; 7(24): 4398-4406
Published online Dec 26, 2019. doi: 10.12998/wjcc.v7.i24.4398
Published online Dec 26, 2019. doi: 10.12998/wjcc.v7.i24.4398
KIT and platelet-derived growth factor receptor α wild-type gastrointestinal stromal tumor associated with neurofibromatosis type 1: Two case reports
You-Wei Kou, Department of Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Ying Zhang, Ya-Ping Fu, Zhe Wang, Department of Pathology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Author contributions: Wang Z and Kou YW conceived the study concept, conducted the analyses, and drafted the manuscript; Wang Z and Fu YP collected clinical samples and analyzed clinical data; Zhang Y performed and analyzed DNA sequencing experiments; Fu YP assisted with figures and experimental design; Wang Z and Kou YW developed the theoretical frameworks, interpreted data, and critically reviewed the manuscript; All authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China , No. 81601692 ; Program of Liaoning Province Department of Education , No. LK2016002 .
Informed consent statement: Consent was obtained from the patients.
Conflict-of-interest statement: The authors declare no conflict of interest.
CARE Checklist (2016) statement: The manuscript was revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Zhe Wang, PhD, Associate Professor, Department of Pathology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. wangz@sj-hospital.org
Telephone: +86-24-9661575211 Fax: +86-24-9661575211
Received: September 27, 2019
Peer-review started: September 27, 2019
First decision: November 19, 2019
Revised: November 22, 2019
Accepted: November 26, 2019
Published online: December 26, 2019
Processing time: 89 Days and 4.2 Hours
Peer-review started: September 27, 2019
First decision: November 19, 2019
Revised: November 22, 2019
Accepted: November 26, 2019
Published online: December 26, 2019
Processing time: 89 Days and 4.2 Hours
Core Tip
Core tip: Gastrointestinal stromal tumors (GISTs) associated with neurofibromatosis are uncommon compared to their gastrointestinal counterparts. Here we reported two cases of KIT and platelet-derived growth factor receptor α wild-type GISTs with neurofibromatosis type 1. Although GISTs with neurofibromatosis type 1 have morphologic and immunohistochemical similarities with common GISTs, the pathogenesis, incidence, genetic background, and prognosis are not completely known. A medical history of neurofibromatosis type 1 in a patient who has gastrointestinal bleeding or anemia and an intra-abdominal mass with nonspecific computed tomography features may help in diagnosing GIST by virtue of the well-known association of these two entities.