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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 26, 2019; 7(24): 4384-4390
Published online Dec 26, 2019. doi: 10.12998/wjcc.v7.i24.4384
Published online Dec 26, 2019. doi: 10.12998/wjcc.v7.i24.4384
Spontaneous ovarian hyperstimulation syndrome: Report of two cases
Juan Gui, Jie Zhang, Wang-Ming Xu, Lei Ming, Reproductive Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province China
Juan Gui, Wang-Ming Xu, Lei Ming, Assisted Reproduction and Embryogenesis Clinical Research Center of Hubei Province, Wuhan 430060, Hubei Province, China
Author contributions: Gui J and Zhang J were the patient’s attending doctors, contributed to manuscript drafting, and analyzed and interpreted the imaging findings; Xu WM and Ming L were responsible for the revision of the manuscript. All authors issued final approval for the version to be submitted.
Supported by the National Natural Science Foundation of China , No. 81601248 .
Informed consent statement: Written informed consent was obtained from the patients for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Lei Ming, MD, Professor, Reproductive Center, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan 430060, Hubei Province, China. rmobg2015@163.com
Telephone: +86-27-88041911-81570 Fax: +86-27-88041911-81571
Received: September 5, 2019
Peer-review started: September 5, 2019
First decision: September 23, 2019
Revised: November 1, 2019
Accepted: November 23, 2019
Article in press: November 23, 2019
Published online: December 26, 2019
Processing time: 111 Days and 6.7 Hours
Peer-review started: September 5, 2019
First decision: September 23, 2019
Revised: November 1, 2019
Accepted: November 23, 2019
Article in press: November 23, 2019
Published online: December 26, 2019
Processing time: 111 Days and 6.7 Hours
Core Tip
Core tip: Spontaneous ovarian hyperstimulation syndrome (sOHSS) is extremely rare. It is always confused with ovarian tumors due to their similar symptoms. Here we report two cases of sOHSS, one woman with a singleton gestation developing sOHSS in the first trimester who conceived naturally and the other with a twin pregnancy in the second trimester after a thawed embryo transfer cycle. The first line investigation for the diagnosis is pelvic ultrasonography. Since sOHSS cannot be predicted, patients with a history of OHSS should be closely monitored. The primary management option is conservative therapy. Single embryo transfer may decrease the risk of developing severe OHSS in assisted reproductive cases.