Case Report
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 26, 2019; 7(24): 4377-4383
Published online Dec 26, 2019. doi: 10.12998/wjcc.v7.i24.4377
Hydroxychloroquine-induced renal phospholipidosis resembling Fabry disease in undifferentiated connective tissue disease: A case report
Song-Zhao Wu, Xiang Liang, Jian Geng, Meng-Bi Zhang, Na Xie, Xiao-Yan Su
Song-Zhao Wu, Xiang Liang, Meng-Bi Zhang, Na Xie, Xiao-Yan Su, Nephrology Department, Tungwah Hospital of Sun Yat-Sen University, Dongguan 523000, Guangdong Province, China
Jian Geng, Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong Province, China
Author contributions: Wu SZ and Liang X contributed equally to this work; Su XY analyzed the samples pathologically and revised the manuscript; Wu SZ analyzed the samples pathologically and wrote the manuscript; Geng J analyzed the samples pathologically; Liang X provided the clinical information; Zhang MB and Xie N were involved in collecting and analyzing the data; all authors have read and approved the final manuscript.
Supported by the Dongguan Social Science and Technology Development Project, No. 2018507150461629.
Informed consent statement: Consent was obtained from the patient for publication of this report.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The guidelines of the CARE Checklist have been adopted.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xiao-Yan Su, MD, Chief Doctor, Department Head, Nephrology Department, Tungwah Hospital of Sun Yat-Sen University, No. 1, Dongcheng East Road, Dongcheng District, Dongguan 523000, Guangdong Province, China. suxiaoyan769@hotmail.com
Telephone: +86-13556758929 Fax: +86-769-22471628
Received: September 4, 2019
Peer-review started: September 4, 2019
First decision: September 23, 2019
Revised: November 8, 2019
Accepted: November 23, 2019
Article in press: November 23, 2019
Published online: December 26, 2019
Core Tip

Core tip: Hydroxychloroquine-induced renal phospholipidosis is characterised by zebra bodies and myelin figures, mimicking nephropathy of Fabry disease. It reminds that clinical application of hydroxychloroquine should be careful. Moreover, drug-induced renal phospholipidosis should be considered as a differential diagnosis, especially when zebra bodies and myelin figures are found in the kidney.