Case Report
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 26, 2019; 7(24): 4285-4291
Published online Dec 26, 2019. doi: 10.12998/wjcc.v7.i24.4285
Successful treatment of warfarin-induced skin necrosis using oral rivaroxaban: A case report
Momoka Kamada, Tsuneaki Kenzaka
Momoka Kamada, Department of Internal Medicine, Hyogo Prefectural Tamba Medical Center, Tamba 669-3395, Japan
Tsuneaki Kenzaka, Division of Community Medicine and Career Development, Kobe University Graduate School of Medicine, Kobe 652-0032, Japan
Author contributions: Kamada M managed the case and redaction and correction of the manuscript; Kenzaka T assisted with redaction, correction, and reconstruction of the manuscript; all authors read and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor of this journal.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist statement, and the manuscript was prepared and revised according to the CARE Checklist statement.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Tsuneaki Kenzaka, MD, PhD, Professor, Division of Community Medicine and Career Development, Kobe University Graduate School of Medicine, 2-1-5, Arata-cho, Hyogo-ku, Kobe 652-0032, Japan. smile.kenzaka@jichi.ac.jp
Telephone: +81-78-3826732 Fax: +81-78-3826283
Received: September 2, 2019
Peer-review started: September 2, 2019
First decision: November 13, 2019
Revised: November 17, 2019
Accepted: November 30, 2019
Article in press: November 30, 2019
Published online: December 26, 2019
Core Tip

Core tip: We present a serious case of warfarin-induced skin necrosis that was successfully treated with oral rivaroxaban, a factor Xa inhibitor. Administration of direct oral anticoagulants instead of warfarin is important in patients with decreased protein S and C activity.