Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 6, 2019; 7(23): 3971-3979
Published online Dec 6, 2019. doi: 10.12998/wjcc.v7.i23.3971
Published online Dec 6, 2019. doi: 10.12998/wjcc.v7.i23.3971
Comparison of intra-articular injection of parecoxib vs oral administration of celecoxib for the clinical efficacy in the treatment of early knee osteoarthritis
Lu Lu, Yu Xie, Ke Gan, Department of Rheumatology, Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of Chinese Medicine), Nanjing 210029, Jiangsu Province, China
Xiao-Wen Huang, Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Nanjing 210029, Jiangsu Province, China
Author contributions: Lu L and Huang XW contributed to study conception and design; Lu L, Xie Y and Gan K contributed to data acquisition, data analysis and interpretation, and writing of article; all of authors contributed to editing, reviewing and final approval of article.
Supported by National Natural Science Foundation of China, NO. 81774274 ; and Project of Jiangsu Provincial Hospital of Traditional Chinese Medicine, NO. Y19058 .
Institutional review board statement: The study was approved by the Ethics Committee of Affiliated Hospital of Nanjing University of Chinese Medicine.
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: All authors have declared that no conflict of interest exists.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement, and the manuscript was prepared and revised according to the STROBE Statement.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xiao-Wen Huang, MD, Professor, Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), No. 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. jiangsuaaa@aliyun.com
Telephone: +86-25-86624213 Fax: +86-25-86624213
Received: September 30, 2019
Peer-review started: September 30, 2019
First decision: October 23, 2019
Revised: November 5, 2019
Accepted: November 15, 2019
Article in press: November 15, 2019
Published online: December 6, 2019
Peer-review started: September 30, 2019
First decision: October 23, 2019
Revised: November 5, 2019
Accepted: November 15, 2019
Article in press: November 15, 2019
Published online: December 6, 2019
Core Tip
Core tip: Among patients with early knee osteoarthritis, intra-articular injection of parecoxib can significantly improve clinical symptoms and avoid the adverse events associated with long-term oral use of non-steroid anti-inflammatory drugs. This treatment can be a suitable treatment alternative.