Case Report
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 26, 2019; 7(22): 3881-3886
Published online Nov 26, 2019. doi: 10.12998/wjcc.v7.i22.3881
Apatinib for treatment of a pseudomyxoma peritonei patient after surgical treatment and hyperthermic intraperitoneal chemotherapy: A case report
Rong Huang, Xiu-Ling Shi, Yun-Fei Wang, Fei Yang, Ting-Tao Wang, Cun-Xu Peng
Rong Huang, Fei Yang, Department of Clinical Medicine, Jining Medical University, Jining 272000, Shandong Province, China
Xiu-Ling Shi, Yun-Fei Wang, Ting-Tao Wang, Cun-Xu Peng, Department of Gynecology, The Affiliated Hospital of Jining Medical University, Jining Medical University, Jining 272000, Shandong Province, China
Author contributions: Huang R drafted, reviewed, and revised the manuscript; Peng CX and Wang TT were the primary physicians during the patient’s inpatient stay; Shi XL provided the images; Wang YF and Yang F were involved in the editing and overseeing of the text; all authors have read and approved the final manuscript.
Informed consent statement: Informed consent as documented by signature was obtained from the patient.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Cun-Xu Peng, Doctor, Professor, Surgeon, Department of Gynecology, The Affiliated Hospital of Jining Medical University, Jining Medical University, 89 Guhuai Road, Jining 272000, Shandong Province, China. pengcunxu@aliyun.com
Telephone: +86-17562232048
Received: July 20, 2019
Peer-review started: July 23, 2019
First decision: September 9, 2019
Revised: September 17, 2019
Accepted: October 5, 2019
Article in press: October 5, 2019
Published online: November 26, 2019
Core Tip

Core tip: The preferred treatment for pseudomyxoma peritonei (PMP) is surgery, but it is easy to relapse after surgery. There is currently no good treatment for patients with postoperative recurrence. In this work, a PMP patient received apatinib for recurrent abdominal distension after surgical treatment and hyperthermic intraperitoneal chemotherapy. After treatment with apatinib, the recurrence time was significantly prolonged. Apatinib, a small-molecule oral inhibitor with anti-angiogenic function, may be an option for recurrent PMP after surgical treatment.