Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2019; 7(20): 3226-3236
Published online Oct 26, 2019. doi: 10.12998/wjcc.v7.i20.3226
Published online Oct 26, 2019. doi: 10.12998/wjcc.v7.i20.3226
Longitudinal observation of intraocular pressure variations with acute altitude changes
Yuan Xie, Yun-Xiao Sun, Di-Ya Yang, Yi-Quan Yang, Shu-Ning Li, Ning-Li Wang, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing 100730, China
Yuan Xie, Yun-Xiao Sun, Yi-Quan Yang, Kai Cao, Ning-Li Wang, Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China
Ying Han, Department of Ophthalmology, University of California, San Francisco, CA 94143, United States
Xue Li, Xin-Xin Lu, Department of Laboratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
Shi-Zheng Wu, Departments of Neurology, the Qinghai Provincial People's Hospital, Xining 810007, Qinghai Province, China
Author contributions: Xie Y, Sun YX, Yang DY, Wu SZ, Wang NL designed research; Sun YX, Yang YQ, Li X, Lu XX, Li SN performed research; Xie Y, Cao K cleaned and analyzed data; and Xie Y, Sun YX, Yang DY wrote the paper, Han Y and Wang NL revised the manuscript.
Supported by the National Natural Science Foundation of China , No. 81730027 ; Beijing Natural Science Foundation , No. 7162037 ; and The Capital Health Research and Development of Special Foundation , No. ZYLX201501 .
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Beijing Tongren Hospital (Beijing China).
Clinical trial registration statement: The study was registered at http://www.chictr.org.cn (Study NO. ChiCTR1800015513).
Informed consent statement: All study participants, provided written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to this report.
Data sharing statement: There is no additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ning-Li Wang, MD, PhD, Chairman, Chief Doctor, Director, Professor, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing Institute of Ophthalmology, 17 Hougou Lane, Chongwenmen, Beijing 100005, China. wningli@vip.163.com
Telephone: +86-10-58269968 Fax: +86-10-58269920
Received: September 5, 2019
Peer-review started: September 5, 2019
First decision: September 23, 2019
Revised: October 13, 2019
Accepted: October 15, 2019
Article in press: October 15, 2019
Published online: October 26, 2019
Peer-review started: September 5, 2019
First decision: September 23, 2019
Revised: October 13, 2019
Accepted: October 15, 2019
Article in press: October 15, 2019
Published online: October 26, 2019
Core Tip
Core tip: Intraocular pressure (IOP) in the lowlanders gradually reduced as altitude elevated in stages. Higher baseline IOP correlated with greater IOP changes in the lowlanders. Lower systemic oxygen saturation was associated with lower IOP as altitude increases. IOP may not be a useful screening method for incipient and potentially harmful altitude-dependent diseases. The findings may provide a potential environmental factor that can lower IOP, which deserves further study.