Retrospective Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2019; 7(20): 3202-3207
Published online Oct 26, 2019. doi: 10.12998/wjcc.v7.i20.3202
Rh-incompatible hemolytic disease of the newborn in Hefei
Shao-Hua Bi, Liang-Liang Jiang, Li-Ying Dai, Hong Zheng, Jian Zhang, Li-Li Wang, Chao Wang, Qiao Jiang, Yu Liu, Yong-Li Zhang, Juan Wang, Chao Zhu, Guang-Hui Liu, Ru-Jeng Teng
Shao-Hua Bi, Li-Ying Dai, Hong Zheng, Jian Zhang, Yu Liu, Yong-Li Zhang, Juan Wang, Guang-Hui Liu, Divisions of Neonatology, Anhui Provincial Children’s Hospital, Hefei 230022, Anhui Province, China
Liang-Liang Jiang, Pediatrics Neurology, Anhui Provincial Children’s Hospital, Hefei 230022, Anhui Province, China
Li-Li Wang, Chao Zhu, Division of Neonatology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Chao Wang, Hefei Blood Center, Hefei 230022, Anhui Province, China
Qiao Jiang, Clinical pathology, Anhui Provincial Children’s Hospital, Hefei 230022, Anhui Province, China
Ru-Jeng Teng, Division of Neonatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, United States
Author contributions: Bi SH and Teng RJ designed the research; Bi SH, Liu GH, and Teng RJ drafted the manuscript; Bi SH, Jiang LL, Dai LY, Zheng H, Zhang J, Liu Y, Zhang YL, and Wang J obtained the informed consents reviewed the medical records; Wang C and Jiang Q performed the laboratory tests; Bi SH, Zhu C, Liu GH, and Teng RJ performed the data analysis; Wang LL, Zhu C, Liu GH, and Teng FJ revised the manuscript; Bi SH, Zhu C, Liu GH, and Teng RJ finalized the manuscript.
Institutional review board statement: See uploaded file for IRB approval in Chinese.
Conflict-of-interest statement: The authors report no relevant conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Data sharing statement: Deidentified raw data can be obtained from the authors upon official request for research purpose only.
Corresponding author: Guang-Hui Liu, MD, Chief Doctor, Division of Neonatology, Anhui Provincial Children’s Hospital, Anhui Medical University, Wangjiang E. Rd, Hefei 230022, Anhui Province, China. lgh508@sina.com
Telephone: +86-551-62237807
Received: July 23, 2019
Peer-review started: July 23, 2019
First decision: September 9, 2019
Revised: September 22, 2019
Accepted: October 5, 2019
Article in press: October 5, 2019
Published online: October 26, 2019
Processing time: 94 Days and 13.6 Hours
Core Tip

Core tip: Rh-hemolytic disease of the newborn (HDN) is more commonly seen after the change of national population policy in China. Different from Caucasian, the most common antibody that causes Rh-HDN in Chinese neonates is the anti-E antibody. The severity of anti-E Rh-HDN seems no less than anti-D Rh-HDN since most of our indexed cases were qualified for blood exchange transfusion. This emerging medical problem requires a nationwide collaboration of research in order to establish evidence-based guidelines for Chinese population.