Observational Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2019; 7(19): 2942-2952
Published online Oct 6, 2019. doi: 10.12998/wjcc.v7.i19.2942
Association of stiff-person syndrome with autoimmune endocrine diseases
Yi-Yin Lee, I-Wen Chen, Szu-Tah Chen, Chih-Ching Wang
Yi-Yin Lee, I-Wen Chen, Szu-Tah Chen, Chih-Ching Wang, Department of Internal Medicine, Division of Endocrinology and Metabolism, Chang Gung Memorial Hospital, Taoyuan City 333, Taiwan
Author contributions: Lee YY wrote the manuscript, analyzed the data, and contributed to discussion; Wang CC analyzed the data and contributed to discussion; Chen IW and Chen ST contributed to discussion and reviewed/edited the manuscript; Wang CC is the guarantor of this work, has full access to all the data in the study, and takes responsibility for the integrity of the data.
Institutional review board statement: The study was reviewed and approved by the Chang Gung Memorial Hospital Institutional Review Board.
Informed consent statement: This study was approved by the Institutional Review Board of Chang Gung Memorial Hospital, and informed consent was not required because that data was drawn from observing behavior and did not contain identifiable information.
Conflict-of-interest statement: The authors report no relevant conflicts of interest.
Data sharing statement: The authors confirm that the data supporting the findings of this study are available within the article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Chih-Ching Wang, MD, Attending Doctor, Endocrinologist, Department of Internal Medicine, Division of Endocrinology and Metabolism, Chang Gung Memorial Hospital, No. 5, Fuxing Street, Guishan District, Taoyuan City 333, Taiwan. p122020223@cgmh.org.tw
Telephone: +886-3-3281200 Fax: +886-3-3288257
Received: June 27, 2019
Peer-review started: June 29, 2019
First decision: July 31, 2019
Revised: August 14, 2019
Accepted: August 27, 2019
Article in press: August 27, 2019
Published online: October 6, 2019
Processing time: 95 Days and 8.9 Hours
Core Tip

Core tip: Stiff-person syndrome (SPS) is an uncommon disorder that causes significant disability. Presence of typical clinical symptoms and anti-glutamic acid decarboxylase antibody are important clues for diagnosis. Several autoimmune diseases can be screened with related autoantibodies in SPS patients, and early diagnosis and appropriate treatment are significant to improve the prognosis of SPS. Recognizing these comorbid conditions can help avoid missing or delaying diagnosis in SPS patients.