Case Report
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 26, 2019; 7(18): 2794-2801
Published online Sep 26, 2019. doi: 10.12998/wjcc.v7.i18.2794
Liver re-transplantation for donor-derived neuroendocrine tumor: A case report
Anna Mrzljak, Branislav Kocman, Anita Skrtic, Ivana Furac, Jelena Popic, Lucija Franusic, Renata Zunec, Davor Mayer, Danko Mikulic
Anna Mrzljak, Department of Medicine, Merkur University Hospital, School of Medicine, University of Zagreb, Zagreb 10000, Croatia
Branislav Kocman, Danko Mikulic, Department of Surgery, Merkur University Hospital, Zagreb 10000, Croatia
Anita Skrtic, Department of Pathology and Cytology, Merkur University Hospital, School of Medicine, University of Zagreb, Zagreb 10000, Croatia
Ivana Furac, DNA Laboratory, Institute of Forensic Medicine and Criminalistics, School of Medicine, University of Zagreb, Zagreb 10000, Croatia
Jelena Popic, Department of Radiology, Merkur University Hospital, School of Medicine, University of Zagreb, Zagreb 10000, Croatia
Lucija Franusic, School of Medicine, University of Zagreb, Zagreb 10000, Croatia
Renata Zunec, Department for Tissue Typing, Clinical Hospital Centre Zagreb, Zagreb 10000, Croatia
Davor Mayer, Institute of Forensic Medicine and Criminalistics, School of Medicine, University of Zagreb, Zagreb 10000, Croatia
Author contributions: Mrzljak A and Franusic L made contributions to the conception and design of the study, acquisition of the data, and drafting of the manuscript; Kocman B was the patient’s surgeon; Skrtic A and Popic J analyzed and interpreted the imaging findings; Furac I and Mayer D were involved in genetic analysis; Zunec R was involved in acquisition of donor data; Mikulic D made contributions to the study design and was involved in critically revising the manuscript; All authors read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2013), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Anna Mrzljak, MD, PhD, Assistant Professor, Department of Medicine, Merkur University Hospital, School of Medicine, University of Zagreb, Salata 3b, Zajceva 19, Zagreb 10000, Croatia. anna.mrzljak@mef.hr
Telephone: +385-1-2431016
Received: June 19, 2019
Peer-review started: June 26, 2019
First decision: August 1, 2019
Revised: August 5, 2019
Accepted: August 20, 2019
Article in press: August 20, 2019
Published online: September 26, 2019
Processing time: 98 Days and 1.9 Hours
Core Tip

Core tip: Donor-origin neuroendocrine neoplasm is a rare but well-recognized complication after liver transplantation. The management is individualized and liver re-transplantation may be considered a long-term treatment option. However, the benefits of graft explantation should be weighed against the risks of liver re-transplantation and the likelihood of neuroendocrine neoplasm dissemination beyond the graft.