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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 26, 2019; 7(18): 2734-2745
Published online Sep 26, 2019. doi: 10.12998/wjcc.v7.i18.2734
Published online Sep 26, 2019. doi: 10.12998/wjcc.v7.i18.2734
Characterization of microbiota in systemic-onset juvenile idiopathic arthritis with different disease severities
Yan-Qing Dong, Wei Wang, Ji Li, Ming-Sheng Ma, Lin-Qing Zhong, Qi-Jiao Wei, Hong-Mei Song, Department of Pediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Author contributions: All authors helped to perform the research; Dong YQ, Wang W, and Song HM contributed to the study conception and design, performing of the procedures, manuscript writing, and data analysis; Li J and Ma MS contributed to data acquisition and performing of the procedures; Zhong LQ and Wei QJ contributed to data analysis and article editing and reviewing.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.
Informed consent statement: Written informed consent was obtained from one of the parents of each participant on the day of sample collection.
Conflict-of-interest statement: All authors declare no conflicts of interest related to this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hong-Mei Song, MD, PhD, Chief Doctor, Department of Pediatrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Shuaifuyuan Road, Beijing 100730, China. songhm1021@hotmail.com
Telephone: +86-10-69156271 Fax: +86-10-69156271
Received: March 29, 2019
Peer-review started: April 4, 2019
First decision: June 19, 2019
Revised: July 17, 2019
Accepted: July 27, 2019
Article in press: July 27, 2019
Published online: September 26, 2019
Processing time: 179 Days and 16.7 Hours
Peer-review started: April 4, 2019
First decision: June 19, 2019
Revised: July 17, 2019
Accepted: July 27, 2019
Article in press: July 27, 2019
Published online: September 26, 2019
Processing time: 179 Days and 16.7 Hours
Core Tip
Core tip: In recent decades, the potential role of gut microbiome in modulating host homeostasis has gained considerable attention. This is the first report of microbiota composition in systemic-onset juvenile idiopathic arthritis (SoJIA) children. Our results demonstrate that the composition of the intestinal microbiota is different in SoJIA patients compared with healthy children. The perturbed microbiota present partial restoration in inactive status patients. Characterizing intestinal microbiomes may help to understand the pathogenesis of SoJIA. Modifications of the microbiota may be a new way of preventing and managing SoJIA.