Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2019; 7(16): 2269-2286
Published online Aug 26, 2019. doi: 10.12998/wjcc.v7.i16.2269
Published online Aug 26, 2019. doi: 10.12998/wjcc.v7.i16.2269
Surveillance and diagnosis of hepatocellular carcinoma: A systematic review
Sonia Pascual, Cayetano Miralles, Liver Unit, Hospital General Universitario de Alicante, Alicante 03010, Spain
Sonia Pascual, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, CIBEREHD, Alicante 03010, Spain
Juan M Bernabé, Javier Irurzun, Mariana Planells, Radiology Department, Hospital General Universitario de Alicante, Alicante 03010, Spain
Author contributions: Pascual S, Miralles C, Bernabé JM, Irurzun J, and Planells M contributed equally to the work; Pascual S conceptualized and designed the review and drafted the initial manuscript; All authors reviewed and approved the final manuscript as submitted.
Conflict-of-interest statement: No conflict of interest to declare.
PRISMA 2009 Checklist statement: This systematic review was conducted according to the PRISMA guidelines.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Sonia Pascual, MD, Staff Physician, Liver Unit, Hospital General Universitario de Alicante, HGU Alicante, C/ Pintor Baeza 11, Alicante 03010, Spain. pascual_son@gva.es
Telephone: +34-96-5933468 Fax: +34-96-5933469
Received: March 26, 2019
Peer-review started: March 26, 2019
First decision: May 24, 2019
Revised: July 4, 2019
Accepted: July 27, 2019
Article in press: July 27, 2019
Published online: August 26, 2019
Processing time: 153 Days and 9.6 Hours
Peer-review started: March 26, 2019
First decision: May 24, 2019
Revised: July 4, 2019
Accepted: July 27, 2019
Article in press: July 27, 2019
Published online: August 26, 2019
Processing time: 153 Days and 9.6 Hours
Core Tip
Core tip: Hepatocellular carcinoma is one of the tumors with the worst prognosis and the 5-year survival is discouraging. The advantages of surveillance of hepatocellular carcinoma in patients with cirrhosis remains controversial, but the best strategy considered is to diagnose the tumor in early stage, which gives the opportunity to access better curative treatment. The current review will focus on the more recent available evidence about surveillance and diagnosis of hepatocellular carcinoma.