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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2019; 7(16): 2238-2246
Published online Aug 26, 2019. doi: 10.12998/wjcc.v7.i16.2238
Published online Aug 26, 2019. doi: 10.12998/wjcc.v7.i16.2238
TAZ and myostatin involved in muscle atrophy of congenital neurogenic clubfoot
Jia-Xing Sun, Ze-Yu Yang, Li-Mei Xie, Bing Wang, Ai-Lu Cai, Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Ning Bai, Key Laboratory of Medical Cell Biology, Ministry of Education; Institute of Translational Medicine, China Medical University, Liaoning Province Collaborative Innovation Center of Aging Related Disease Diagnosis and Treatment and Prevention, Shenyang 110004, Liaoning Province, China
Author contributions: Sun JX, Yang ZY, and Cai AL designed research; Sun JX, Xie LM, and Wang B performed clinical ultrasound examination; Sun JX and Bai N performed the biological experiments; Sun JX and Yang ZY analyzed data; and Sun JX, Yang ZY, and Cai AL wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Shengjing Hospital of China Medical University.
Informed consent statement: The clinical data used in this study were anonymous.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ai-Lu Cai, MD, PhD, Professor, Department of Ultrasound, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110004, Liaoning Province, China. caial1224@sina.com
Telephone: +86-24-9661574194
Received: April 25, 2019
Peer-review started: May 7, 2019
First decision: May 31, 2019
Revised: June 23, 2019
Accepted: July 27, 2019
Article in press: July 27, 2019
Published online: August 26, 2019
Processing time: 123 Days and 17.9 Hours
Peer-review started: May 7, 2019
First decision: May 31, 2019
Revised: June 23, 2019
Accepted: July 27, 2019
Article in press: July 27, 2019
Published online: August 26, 2019
Processing time: 123 Days and 17.9 Hours
Core Tip
Core tip: This study aimed to identify muscle atrophy in fetal neurogenic clubfoot, detect expression of TAZ and myostatin in gastrocnemius muscle, and establish the mechanisms through which TAZ antagonizes myostatin-induced atrophy in an in vitro cell model. Muscle atrophy in fetal unilateral clubfoot with nervous system abnormalities was identified by ultrasound. TAZ overexpression in C2C12 myotubes induced atrophy by myostatin. Both TAZ and myostatin are involved in the process of neurogenic clubfoot muscle atrophy, and they are negatively correlated. TAZ antagonizes myostatin-induced myotube atrophy, potentially through regulation of the Akt/forkhead box O4 pathway.