Retrospective Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2019; 7(16): 2204-2216
Published online Aug 26, 2019. doi: 10.12998/wjcc.v7.i16.2204
Incidence of infectious complications is associated with a high mortality in patients with hepatitis B virus-related acute-on-chronic liver failure
Chen Wang, De-Qiang Ma, Sen Luo, Chuan-Min Wang, De-Ping Ding, You-You Tian, Kang-Jian Ao, Yin-Hua Zhang, Yue Chen, Zhong-Ji Meng
Chen Wang, De-Qiang Ma, Sen Luo, Chuan-Min Wang, De-Ping Ding, You-You Tian, Kang-Jian Ao, Yin-Hua Zhang, Yue Chen, Zhong-Ji Meng, Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, China
Zhong-Ji Meng, Institute of Biomedical Research, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei Province, China
Author contributions: All authors helped to perform the research; Wang C, Ma DQ, Luo S, Wang CM, Ding DP, Tian YY, Ao KJ, and Zhang YH collected and analyzed the data; Meng ZJ and Chen Y designed and coordinated the research; Wang C and Meng ZJ wrote the paper; all authors read and approved the manuscript.
Supported by the Foundation for Innovative Research Groups of Natural Science Foundation of Hubei Province of China, No. 2018CFA031; Precision Medical Project Granted by National Key Research and Development Program, No. 2017YFC0908104; Research and Development Project of Science and Technology Plan of Shiyan, No. 18K78; and Key Program for Precision Medicine of Taihe Hospital, No. 2016JZ05.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Shiyan Taihe Hospital.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All authors declare no conflicts of interest related to this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Zhong-Ji Meng, MD, Chief Doctor, Full Professor, Research Scientist, Institute of Biomedical Research, Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine, No. 32, South Renmin Road, Shiyan 442000, Hubei Province, China. zhongji.meng@163.com
Telephone: +86-719-8876628 Fax: +86-719-8876627
Received: April 22, 2019
Peer-review started: April 22, 2019
First decision: May 9, 2019
Revised: June 20, 2019
Accepted: July 20, 2019
Article in press: July 20, 2019
Published online: August 26, 2019
Core Tip

Core tip: Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is the most common type of liver failure with a high mortality and complications. Bacterial and/or fungal infections are the most common complications of liver failure. The aim of this study was to investigate the frequency and role of bacterial and fungal infections in patients with HBV-ACLF. A total of 174 patients with HBV-ACLF were retrospectively analyzed. Patients with infectious complications had a significantly higher mortality (70.18%) than those without (40.00%, 24/60). In conclusion, infections can significantly increase the mortality rate of liver failure.