Observational Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2019; 7(15): 1996-2002
Published online Aug 6, 2019. doi: 10.12998/wjcc.v7.i15.1996
Clinical significance and role of up-regulation of SERPINA3 expression in endometrial cancer
Mian-Li Zhou, Fang-Shan Chen, Hui Mao
Mian-Li Zhou, Fang-Shan Chen, Department of Gynecology and Obstetrics, Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University, Luzhou 646000, Sichuan Province, China
Hui Mao, Department of Oncology, Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University, Luzhou 646000, Sichuan Province, China
Author contributions: Zhou ML, Chen FS, and Mao H designed the study and wrote the manuscript.
Institutional review board statement: The study was approved by Hospital of Traditional Chinese Medicine Affiliated to Southwest Medical University on October 28, 2016 (Research ethics No. CHEC2016-111).
Informed consent statement: All subjects gave informed consent prior to study inclusion.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement, and the manuscript was prepared and revised according to the STROBE Statement.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hui Mao, MD, Professor, Department of Oncology, Traditional Chinese Medicine Hospital Affiliated to Southwest Medical University, No. 182, Chunhui Road, Longmatan District, Luzhou 646000, Sichuan Province, China. 15196087724@163.com
Telephone: +86-830-2397165
Received: April 28, 2019
Peer-review started: May 7, 2019
First decision: May 30, 2019
Revised: June 19, 2019
Accepted: July 3, 2019
Article in press: July 3, 2019
Published online: August 6, 2019
Processing time: 100 Days and 11.2 Hours
Core Tip

Core tip: Serpin peptidase inhibitor, clade A member 3 (SERPINA3) is considered to be associated with several cancers. In this study, the clinical significance and role of SERPINA3 expression in endometrial cancer were investigated. It was found that the expression of SERPINA3 was up-regulated in endometrial cancer and expression of SERPINA3 in endometrial cancer was correlated with pathological grade, clinical stage, vascular invasion, and lymph node metastasis. SERPINA3 has the potential to be used as a biomarker for prognosis and a specific target for targeted therapy in patients with endometrial carcinoma.